延长哌拉西林/他唑巴坦输注时间治疗复杂性尿路感染的临床观察

Clinical Observation of Extending Prolonged Infusion Time of Piperacillin/Tazobactam in the Treatment of Complicated Urinary Tract Infections

目的:评价延长哌拉西林/他唑巴坦(PIP/TAZ)输注时间治疗复杂性尿路感染的疗效及安全性。方法:将我院于2012年10月-2014年10月收治的84例复杂性尿路感染患者按SPSS 15.0软件随机分组程序分为试验组和对照组各42例。试验组予以PIP/TAZ 4.5 g持续静脉泵入,q8 h,静脉泵入时间为3 h;对照组予以PIP/TAZ 4.5 g静脉滴注,q8 h,静脉滴注时间为30 min。两组均以7 d为1个疗程,观察实验室检查指标、降钙素原与血白细胞计数。结果:两组患者治疗后降钙素原均较治疗前明显下降,差异有统计学意义(P<0.05);且治疗后组间比较差异亦有统计学意义(P<0.05)。两组患者治疗后血白细胞计数均较治疗前明显下降,差异有统计学意义(P<0.05);但组间比较差异无统计学意义(P>0.05)。试验组的临床总有效率为85.4%,对照组的临床总有效率为63.4%,差异有统计学意义(P<0.05)。两组不良反应发生率均为2.4%,差异无统计学意义(P>0.05)。结论:延长PIP/TAZ输注时间治疗复杂性尿路感染疗效确切、安全性高。

OBJECTIVE： To evaluate the efficacy and safety of prolonged administration time of piperacillin/tazobactam （PIP/ TAZ） in the treatment of complicated urinary tract infections. METHODS： 84 patients with complicated urinary tract infections in our hospital from Oct. 2012 to Oct. 2014 were randomly divided into test group （n=42） and control group （n=42） by SPSS 15.0 software randomized program. The test group was given PIP/TAZ 4.5 g for 3 h, continuous iv,q8 h; control group was giv- en PIP/TAZ 4.5 g for 30 min, continuous iv, q8 h. The course was 7 d. The laboratory parameters, procalcitonin and white blood cell count were observed. RESULTS： After treatment, the procalcitonin in 2 groups were significantly decreased, with significant difference （P〈0.05） ; there was significant difference between 2 groups （P〈0.05）. Compared with before, the white blood cell count in 2 groups were significantly decreased, with significant difference （P〈0.05）; however, there was no significant differ- ence between 2 groups （P〉0.05）. The total effective rat of test group was 85.4% and it of control group was 63.4%, with signif- icant difference （P〈0.05）. The incidence of adverse reactions in 2 groups was 2.4%, with no significant difference （P〉0.05）. CONCLUSIONS ： Prolonged PIP/TAZ administration time has accurate efficacy and highly safety in the treatment of complicated urinary tract infections.