不同输注方式对帕拉西林-他唑巴坦钠临床疗效影响的Meta分析

A systematic review of clinical outcomes with alternative dosing strategies for piperacillin/tazobactam

目的:系统评价不同输注方式对帕拉西林-他唑巴坦钠临床疗效的影响。方法:在Pub Med,Web of Science,Pro Quest,Embase,Science Direct,Cochrane上检索所有2015年1月1日前所有相关文献,采用Revman 5.3软件进行分析。结果:共纳入2篇RCT和10篇观察性研究文献,结果显示延长给药组或连续给药组相对于传统给药方法,能降低临床死亡率[OR 0.68,CI(0.53,0.88),P=0.003],但临床有效率差异无统计学意义[OR 0.84,CI(0.83,2.50),P=0.20]。结论:帕拉西林-他唑巴坦钠采用延长或连续输注的方式可以降低死亡率,临床值得推荐。

Objective： To systematically evaluate the outcome of alternative closing strategies for piperacillin- tazobaetam. Methods： Databases including PubMed, Web of Science, ProQuest, Embase,ScienceDirect, and Co- ehrane before January 1st 2015 were searehed with key words to colleet all the related references. Results： According to the inclusion and exclusion criteria, a total of 12 articles were included, which were 2 RCT and 10 observational studies. Compared to traditional infusion approach, extended or continuous infusion group had significantly lower mortality rate [ OR 0. 68, CI （0.53, 0. 88）, P =0. 003 ]. No statistical diforence was observed for clinical cure rate [ OR 0. 84, CI （0.83, 2.50）, P =0. 201 between two dosing regimens. Conclusion： Extended or continuous infu- sion strategy of piperacillin/tazobactam shouht be recommended for clinical use as its mortality rate is lower.