稳定期慢性阻塞性肺疾病与血清炎性因子的相关性临床治疗分析

Correlation analysis of clinical stable chronic obstructive pulmonary disease and serum inflammatory factors

目的分析稳定期COPD与血清炎性因子的相关性。方法搜集2012年12月至2014年11月我院稳定期COPD43例作为研究组，对照组选取同期健康吸烟者43例。分别采集研究组与对照组外周静脉血，取标本上清液，采用酶联免疫法进行检测，观察研究组与对照组的单核细胞趋化蛋白1（MCP1）、C反应蛋白（CRP）、肿瘤坏死因子α（TNF-α）、脑钠肽（BNP）水平，并对两组人员的检测结果进行对比。分析研究组不同圣乔治呼吸问卷（SGRQ）评分、BODE指数分级患者检测水平，对检测指标与疾病相关性进行研究。结果研究组与对照组血清炎性因子对比，研究组各项指标较高，差异有统计学意义（P〈0．05）。检测结果显示疾病与MCP-1、CRP、TNF-α、BNP密切相关。结论稳定期COPD患者MCP-1、CRP、TNF-α、BNP等血清炎性因子明显升高，与疾病有一定相关性。因此，对于此种疾病的治疗，应当充分考虑血清炎性因子的影响，并明确影响程度，确保疾病诊断的准确性，为后续治疗奠定基础。

Objective To analyze the stable chronic obstructive pulmonary disease and serum inflammatory factors relevant. Methods December 2012-November 2014 hospital in stable chronic obstructive pulmonary disease and 43 cases as the study group and the control group,43 cases of healthy smokers choose the same period. Were collected from the study group and the control group, peripheral blood, specimens supernatant were detected by enzyme-linked immunosorbent assay, monocyte chemoattractant protein-1 （MCP-1）, C reactive protein （CRP）, tumor necrosis factor-α （TNF-α）, brain natriuretic peptide （BNP） levels were observed in the study group and the control group,and both groups. The test results were compared. Analysis of different groups SGRQ score, BODE index patient classification level of detection, detection indicators related diseases research. Results The study group and the control group, serum inflammatory factors contrast, the higher the index study group, significant difference was statistically significant （ P 〈0.05）. Test results showed disease closely related to MCP-1, CRP, TNF-α,BNP. Conclusions Patients with stable chronic obstructive pulmonary disease MCP-1,CRP, TNF-α,BNP serum inflammatory factors, such as increased significantly with the disease have a certain relevance. Therefore,for the treatment of this disease, should take full account of serum inflammatory factors,and clearly the degree of influence to ensure the accuracy of disease diagnosis, lay the foundation for follow-up treatment.