腺病毒载体在呼吸系统疾病基因治疗中的应用

Application of adenovirus vector in the gene therapy of respiratory disease

腺病毒载体因具有高滴度、转染效率高、可转染至非分裂期及分裂期细胞、给药途径多等优点，广泛应用于疾病的基因治疗。呼吸系统疾病是一类严重影响人类生命健康的疾病，近年来关于呼吸系统疾病基因治疗的研究引起了国内外学者的关注。现对腺病毒载体在呼吸系统疾病基因治疗中的应用作一综述。

Because adenovirus vector has high titer,the advantages of high transfection efficiency, ability to transfected to non-dividing and dividing cells, multiple routes of administration,it is widely used in gene therapy. Respiratory disease is a type of serious diseases affecting human life and health. Recent research on gene therapy for respiratory diseases caused concern of domestic and foreign scholars. The application of adenovirus vector in gene therapy of respiratory diseases is summarized.