SLIT2和TRPV1在子宫腺肌病中的表达及意义

The expression and clinical significance of SLIT2 and TRPV1 in adenomyosis

目的:研究SLIT2和瞬时受体感受器电位香草酸亚型1(TRPV1)在子宫腺肌病中的表达及其与子宫腺肌病的关系,为子宫腺肌病的诊断和治疗提供新的方法。方法:以35例子宫腺肌病患者的在位及同源异位内膜作为实验组样本,20位非子宫腺肌病患者的正常子宫内膜作为对照组样本,免疫组化分析SLIT2和TRPV1的表达。结果:①SLIT2在异位内膜的阳性表达率大于正常及在位内膜(P<0.01);②TRPV1在异位内膜的表达高于正常及在位内膜,组间比较差异有统计学意义(P<0.01);③SLIT2及TPPV1与痛经严重程度呈正相关(r=0.627,P<0.01;r=0.583,P<0.01);④SLIT2与TRPV1的表达呈正相关(r=0.376,P=0.026)。结论:SLIT2和TRPV1在异位子宫内膜表达明显增强,SLIT2和TRPV1表达强度与子宫腺肌病痛经严重程度相关。

Objective： To explore the expression and the localization of transient receptor potential vanilloid type I（TR- PV1） and SLIT2 in women with and without adenomyosis. Methods： Ectopic and homologous eutopic endometria from 35 women suffering adenomyosis and endometria from 20 women without adenomyosis were sampled for immunohisto- chemical analysis of TRPV1 and SLIT2. Results： The positive expression rate of SLIT2 in ectopic endometria was significantly greater than those in normal and eutopic endometria （P〈0.01）. Compared with normal and eutopic endometria, the immunoreactivity of TRPV1 was significantly increased in ectopic endometrium （P〈0.01）. The immunoreactivities of both TRPV1 and SLIT2 were positively correlated with the severity of dysmenorrheal （r=0.627 P〈0.01; r = 0.583 P %0.01）. Expressions of SLIT2 and TRPV1 were positively correlated （ r = 0. 376 P = 0.026）. Conclusion： TRPV1 and SLIT2 may be involved in the severity of dysmenorrheal and found to be significant indicators for dysmen- orrheal severity in women with adenomyosis.