血清C肽水平变化与2型糖尿病微血管病变的相关性研究

The relationship of serum C-peptide levels and microvascular complications in type 2diabetes mellitus

目的：探讨T2DM 患者血清C‐P水平变化与微血管病变的关系。方法回顾性分析434例T2DM患者的临床资料，根据ΔC‐P（2 hC‐P －FC‐P）的三分位数由低到高分为ΔC‐P1（≤2.2 ng／ml）、ΔC‐P2（2.3～4.0 ng／ml）和ΔC‐P3（≥4.1 ng／ml）。结果ΔC‐P1组BMI、TG、FC‐P水平较低，病程、HbA1c水平较高（P＜0.05）。血清ΔC‐P水平与BMI、TG水平呈正相关（P＜0.05），与DR、糖尿病慢性肾脏疾病（CKD）发病率、病程、HbA1c水平呈负相关（P＜0.05）。随DR和CKD的进展，ΔC‐P水平逐渐降低。Logistic回归分析显示，在校正相关因素后，较低水平的ΔC‐P是发生微血管并发症的独立危险因素。结论血清ΔC‐P水平是T2DM 微血管并发症的独立相关因素。

Objective To evaluate the relationship between serum C‐P levels and microvascular complications in patients with T 2DM. Methods The clinical data of 434 patients with T2DM were retrospectively analyzed. All subjects were divided into three groups based on ΔC‐P （2 hC‐P - FC‐P） tertiles ：ΔC‐P1（≤2.2 ng/ml） ,ΔC‐P2（2.3～4.0 ng/ml） and ΔC‐P3（≥4.1 ng/ml）. Results The levels of BMI ,TG ,FC‐P were lower ,and the course and HbAl c were higher in ΔC‐P1 group. ΔC‐P level was positively associated with BMI and TG （P〈0.05） ,and negatively associated with prevalence of DR and chronic kidney disease （CKD）in diabetes ,course and HbA1 c.ΔC‐P levels decreased gradually with the progression of DR and CKD. Logistic regression analysis showed that lower ΔC‐P level was the independent risk factor for microvascular complications after adjustment for related risk factors. Conclusion Serum ΔC‐P level is an independent factor for the development of diabetic microvasculr complications in T 2DM.