血清中性粒细胞/淋巴细胞比值与糖尿病视网膜病变的相关性研究被引量：11

Relationship of serum neutrophil-to-lymphocyte ratio with diabetic retinopathy

导出

摘要目的探讨T2DM患者血清中性粒细胞/淋巴细胞比值(NLR)与DR的相关性。方法将128例T2DM患者分为增殖型DR(PDR)者22例、非增殖型DR(NPDR)者44例和单纯T2DM者62例。检测各组FPG、HbA1c、TC、TG和NLR等指标水平。结果Spearman相关性分析显示,DR与T2DM病程、SBP、DBP、FPG、HbA1c、TC、TG、LDL-C、NLR、CKD呈正相关(r=0.524、0.277、0.279、0.194、0.271、0.208、0.223、0.358、0.621、0.362,P<0.05或P<0.01)。Logistic多元回归分析结果显示,T2DM病程、NLR和糖尿病慢性肾脏疾病(CKD)是DR的独立影响因素。结论 NLR与DR存在相关性。 Objective To explore the association between serum neutrophil‐to‐lymphocyte ratio （NLR） and DR in T2DM patients . Methods A total of 128 T2DM patients were recruited and divided into three groups ：PDR group （n=22） ,NPDR group（n= 44） ,and simple T2DM group（n=62） .The levels of FPG ,HbA1 c ,TC ,TG and NLR were measured in each group . Results Spearman correlation analysis revealed that DR was positively correlated with T 2DM duration ,SBP ,DBP ,FPG ,HbA1 c ,TC , TG ,LDL‐C ,NLR ,CKD （r= 0.524 ,0.277 ,0.279 ,0.194 ,0.271 ,0.208 ,0.223 ,0.358 ,0.621 , 0.362 ,P〈0 .05 or P〈0 .01） .Logistic multiple regression analysis showed that ,T2DM duration ,NLR and CKD were independent risk factors for DR . Conclusion NLR level is associated with DR .

作者匡霞王素莉

机构地区武警后勤学院附属医院内分泌科

出处《中国糖尿病杂志》 CAS CSCD 北大核心 2015年第5期438-440,共3页 Chinese Journal of Diabetes

关键词中性粒细胞/淋巴细胞比值糖尿病视网膜病变糖尿病 2型 Neutrophil-to-lymphocyte ratio(NLR) Diabetic retinopathy(DR) Diabetes mellitus,type 2

分类号 R587.2 [医药卫生—内分泌]

引文网络
相关文献

参考文献9

1Kagtelan S, Tomi: M,Gverovi: Antunica A, et al. Inflammation andpharmacological treatment in diabetic retinopathy. Mediators In- flamm,2013,2013:213130.
2Wilkinson CP, Ferris III FL, Klein RE, et al. Proposed interna- tional clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology, 2003,110:1677-1682.
3Stratton IM, Kohner EM, Aldington SJ, et al. UKPDS 50 : risk factors for incidence and progression of retinopathy in type 2 di- abetes over 6 years from diagnosis. Diabetologia, 2001, 44: 156-163.
4Zhang X, Saaddine JB, Chou CF, et al. Prevalence of diabetic retinopathy in the United States, 2005-2008. JAMA, 2010,304 : 349-656.
5Sacks FM, Herrnans MP, Fioretto P, et al. Association between plas- ma triglyeerides and high-density lipoprotein cholesterol and microvas- cular kidney disease and retinopathy in type 2 diabetes mellitus: a global case-control study in 13 countries. Circulation, 2014, 129:999-1008.
6Joussen AM,Poulaki V,Mitsiades N, et al. Suppression of Fas- FasL-induced endothelial cell apoptosis prevents diabetic blood- retinal barrier breakdown in a model of streptozotocin-induced diabetes. FASEB J, 2003,17 : 76:78.
7Sen N, Afsar B, Ozcan F, et al. The neutrophil to lymphocyte ratio was associated with impaired myocardial peKusion and longterm ad- verse outcome in patients with ST-elevated myocardial infarction undergoing primary coronary intervention. Atherosclerosis, 2013, 228:203-210.
8Kern TN Contributions of inflammatory processes to the devel- opment of the early stages of diabetic retinopathy. Exp Diabetes Res, 2007,2007 : 95103.
9Ulu SM, Dogan M, Ahsen A, et al. Neutrophil-to-lymphocyte ratio as a quick and reliable predictive marker to diagnose the severity of diabetic retinopathy. Diabetes Technol Ther, 2013, 15,942-947.