摘要
目的比较不同严重程度的脓毒血症患者的凝血功能差异,探讨凝血功能与脓毒血症病程发展可能存在的相关性。方法回顾性分析128例脓毒血症患者,资料按照PCT和危重评分系统APACHEⅡ进行炎症分级和严重程度进行分级分组,统计分析不同发病进程的脓毒血症患者的凝血功能相关指标(APTT、TT、PT、FIB)差异以及差异与病程的相关性。结果 APACHEⅡ评分分级的细菌性脓毒学症患者的炎症判断指标PCT差异有统计学意义(P<0.01),关联性和相关性分析发现APACHEⅡ评分与PCT的判定标准存在较强的关联性(C>0.60,N>0.06)。不同炎症的程度和脓毒血症病程的凝血指标差异明显,其中PT,APTT和TT明显增加,而FIB明显减少;PCT评分分组中发现仅PT与FIB与炎症指标PCT(2<PCT<10)存在相关性,而APACHEⅡ评分系统分组中危重和非危重组的APACHEⅡ评分与APTT、FIB、APTT存在相关性。结论炎症程度与脓毒血症进程呈明显正相关,而凝血功能的异常贯穿整个脓毒血症发病进程,特别是在细菌性脓毒血症发生的早中期与凝血功能关系密切。
Objective To comparing the difference of different severitily coagulation function in sepsis patients, investi-gating the relationship between coagulation function and develoment of sepsis. Methods Retrospectively analyzed the data of 128 cases of patients with sepsis testing, grouping and grading inflammation and procession by viture of the classification of PCT and severity scoring system of APACHE II,statistically analyed the difference of which coagulation indexes ( APTT, TT, PT, FIB) of different progression of sepsis patients difference,the correlationship between the difference andprogression. Results The signifi-cantly difference of PCT was discovered in pateints with bacterial sepsis grading by APACHE II score,correlation analysis and cor-relation was found a strong correlation existing criteria APACHE II score (C〉0. 60, R〉0. 06). The difference between inflamma-tion and coagulation was significantly,The between coagulation indexes in which PT, APTT and TT increased significantly, and FIB decreased significantly;the PCT score showed that only PT and FIB packetand inflammatory index PCT (2〈PCT〈10)there is a correlation, and the critical and non critical group the APACHE score and APTT the grouping, APACHE II score in the FIB system, there is correlation APTT. Conclusion There was a significant positive correlation between the degree of inflammation and sepsis process. Accross development of sepsis, the abnormal expression of coagulation function was symbol, especially, in ear-ly and mid edge of bacterial sepsis occurring.
出处
《四川医学》
CAS
2015年第4期503-507,共5页
Sichuan Medical Journal
关键词
凝血功能指标
炎症
脓毒血症
indexes of coagulation
inflammation
sepsis