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128例不同严重程度的细菌性脓毒血症患者凝血功能差异分析 被引量:5

Analysis of Difference of Coagulation in Pateins with Spesis Indudced by Bacteria
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摘要 目的比较不同严重程度的脓毒血症患者的凝血功能差异,探讨凝血功能与脓毒血症病程发展可能存在的相关性。方法回顾性分析128例脓毒血症患者,资料按照PCT和危重评分系统APACHEⅡ进行炎症分级和严重程度进行分级分组,统计分析不同发病进程的脓毒血症患者的凝血功能相关指标(APTT、TT、PT、FIB)差异以及差异与病程的相关性。结果 APACHEⅡ评分分级的细菌性脓毒学症患者的炎症判断指标PCT差异有统计学意义(P<0.01),关联性和相关性分析发现APACHEⅡ评分与PCT的判定标准存在较强的关联性(C>0.60,N>0.06)。不同炎症的程度和脓毒血症病程的凝血指标差异明显,其中PT,APTT和TT明显增加,而FIB明显减少;PCT评分分组中发现仅PT与FIB与炎症指标PCT(2<PCT<10)存在相关性,而APACHEⅡ评分系统分组中危重和非危重组的APACHEⅡ评分与APTT、FIB、APTT存在相关性。结论炎症程度与脓毒血症进程呈明显正相关,而凝血功能的异常贯穿整个脓毒血症发病进程,特别是在细菌性脓毒血症发生的早中期与凝血功能关系密切。 Objective To comparing the difference of different severitily coagulation function in sepsis patients, investi-gating the relationship between coagulation function and develoment of sepsis. Methods Retrospectively analyzed the data of 128 cases of patients with sepsis testing, grouping and grading inflammation and procession by viture of the classification of PCT and severity scoring system of APACHE II,statistically analyed the difference of which coagulation indexes ( APTT, TT, PT, FIB) of different progression of sepsis patients difference,the correlationship between the difference andprogression. Results The signifi-cantly difference of PCT was discovered in pateints with bacterial sepsis grading by APACHE II score,correlation analysis and cor-relation was found a strong correlation existing criteria APACHE II score (C〉0. 60, R〉0. 06). The difference between inflamma-tion and coagulation was significantly,The between coagulation indexes in which PT, APTT and TT increased significantly, and FIB decreased significantly;the PCT score showed that only PT and FIB packetand inflammatory index PCT (2〈PCT〈10)there is a correlation, and the critical and non critical group the APACHE score and APTT the grouping, APACHE II score in the FIB system, there is correlation APTT. Conclusion There was a significant positive correlation between the degree of inflammation and sepsis process. Accross development of sepsis, the abnormal expression of coagulation function was symbol, especially, in ear-ly and mid edge of bacterial sepsis occurring.
作者 唐琴
出处 《四川医学》 CAS 2015年第4期503-507,共5页 Sichuan Medical Journal
关键词 凝血功能指标 炎症 脓毒血症 indexes of coagulation inflammation sepsis
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参考文献15

  • 1Wilmore DW, Kehlet H. Management of patients in fast traeksurgery [J]. BMJ, 2001, 322 (7284) ;473-476.
  • 2Comet AD,Smit EG,Beis huizen A,et al. The role of heparin and al- lied compounds in the treatment of sepsis [ J ]. Thromb Haemost, 2007, 98 (3) ;579-586.
  • 3Bernard GR, Vincent J, Laterre P,et al. Efficacy and safety of recom- binant human activated protein C for severesepsis[J]. N Engl J Med, 2001,344:699-707.
  • 4Coalson JJ. Pathophysiology of sepsis, septic shock, and multiple organ failure. In : Perspective on sepsis and septic shock [ M ]. Fullerton, CA : Society of Critical Care Medicine, 1986,27-59.
  • 5Dnbin G1, Koziel J, Pyrc K, et al. Bacterial proteases in disease-role in intracellular survival, evasion of coagulation/fibrinolysis innate de- fenses [ J ]. toxicoses and viral infections [ J ]. Curt Pharm Des, 2013, 19 (6) :1090-1113.
  • 6Esper AM, Moss M, Lewis CA,et al. The role of infectionand comor- bidity:Factors that influence disparitiesin sepsis [ J ]. Crit Care Med, 2006,34:2576-2582.
  • 7蒋力生,陈鹏.脓毒症与内毒素血症的治疗现状与展望[J].中国普外基础与临床杂志,2004,11(6):551-553. 被引量:14
  • 8Palmiere C1, Augsburger M. Markers for sepsis diagnosis in the foren- sic setting : state of the art[ J]. Croat Med J ,2014,55 (2) : 103-114.
  • 9Ramachandran G. Gram-positive and gram-negative bacterial toxins in sepsis:a brief review[ J]. Virulence,2014,5( 1 ) :213-218.
  • 10EbiharaI, NakamuraT, ShimadaN, et al. Effect of hemoperfusion with- polymyxin B-immobilized FiberonPlasma endothelin-landen-dothe- lin-mRNA lnmonoCytes Frompatientswithsepsis [ J ]. Am J Kidney Dis, 1998,32(6) :95.

二级参考文献26

  • 1刘晓蓉,任新生.脓毒症凝血机制及组织因子通路抑制剂治疗的研究现状及治疗进展[J].中国急救医学,2005,25(11):833-835. 被引量:19
  • 2葛庆岗,阴赪宏,文艳,吕旌乔,王谊冰.血清降钙素原与多器官功能障碍综合征严重程度相关性的临床研究[J].中国危重病急救医学,2005,17(12):729-731. 被引量:28
  • 3Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ACCP/ ATS/SIS international sepsis definitions conference. Crit Care Med, 2003,31:1250-1256.
  • 4Vincent JL, Moreno R,Takala J, et al. The SOFA score to describe organ dysfunction/failure. Intensive Care Med, 1996,22:707-710.
  • 5Guven H, Altintop L, Baydin A, et al. Diagnostic value of procalcitonin levels as an early indicator of sepsis. Am J Emerg Med ,2002,20:202-206.
  • 6Balci C,Sungurtekin H, Gurses E, et al. Usefulness of procalcitonin for diagnosis of sepsis in the intensive care unit. Crit Care ,2003,7 : 85 -90.
  • 7Yukioka H, Yoshida G, Kurita S. Plasma procalcitonin in sepsis and organ failure. Ann Acad Med Singapore ,2001,30,528-531.
  • 8Luzzani A, Polati E, Dorizzi R, et al. Comparison of procalcitonin and C-reactive protein as markers of sepsis. Crit Care Med, 2003, 31 : 1737-1741.
  • 9彭文伟,主编.传染病学.第6版,北京:人民卫生出版社,2005,67-68.
  • 10Levi M, van der Poll T, BUller HR. Bidirectional relation between inflammation and coagulation [J]. Circulation, 2004, 109(22) :2698-2704.

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