顺妥敏联合鼻用激素治疗儿童中重度持续性变应性鼻炎的疗效

Shuntuomin VS corticosteroid in treatment of moderate to severe persistent allergic rhinitis in children

目的比较顺妥敏与鼻用激素治疗儿童中重度持续性变应性鼻炎的疗效。方法选择中重度持续性变应性鼻炎患儿232例,采用随机对照研究方法,将受试者随机分为3组,其中顺妥敏与鼻用激素治疗组68例,顺妥敏治疗组72例,鼻用激素治疗组92例,3组使用相同的鼻腔护理及其他治疗。治疗1个月后根据CARAT 10控制量表进行疗效评估,观察3组诱导缓解例数、诱导缓解时间、控制例数、依从性和不良反应等方面是否存在差异。结果联合治疗组(65/68)和顺妥敏组(70/72)缓解率明显高于激素组(80/92),差异有统计学意义(P<0.05);联合治疗组(62/68)控制率明显高于顺妥敏组(34/72)和激素组(73/92),差异有统计学意义(P<0.05);顺妥敏组诱导缓解时间[(4.7±1.84)d]明显低于联合治疗组[(6.6±1.27)d]和激素组[(6.7±2.16)d],差异有统计学意义(P<0.05)。结论顺妥敏可在短期内缓解鼻炎症状,而长期控制还需要联合使用鼻用激素进行治疗。

Objective To compare the effect of Shuntuomin with that of corticosteroid,then have a better decision in the treatment for allergic rhinitis. Methods A total of 232 cases with moderate to severe allergic rhinitis were involved in this randomized controlled stud-y,with 68 cases treated by Shuntuomin and corticosteroid and 72 cases using Shuntuomin,92 cases using corticosteroid two times every day. The basic treatment of three groups was Nuosiqing and Mobijing which were also used twice per day. After one month treatment,the effect, including the relief time,controlment and adverse reaction and so on were assessed using CARAT10. Results There was significant differ-ence between combination treatment groups and two others in the number of relief;Shuntuomin group achieved better effect in relief time, while combination treatment group was also better in controlment. Conclusion Shuntuomin could relieve symptoms of allergic rhinitis in short time,but long time control also need the combined use of corticosteroid.