Effects of progesterone on gastric emptying and intestinal transit in male rats

瞄准：在胃肠的活动性上学习在后叶催产素(OT ) 和 P 之间的孕酮(P) 效果和相互作用的剂量依赖者。方法：以便监视胃的倒空和肠的运输， SD 雄的老鼠与正常经由一根导管被把管子插进盐(3 ml/kg ) 包含 Na (2 )(51 ) CrO (4 )(0.5 microCi/ml ) 和 10% 炭。OT 被溶解进盐的正常， P 被溶解进 75% 酒精。结果：低 P 做(1 mg/kg， i.p ) 提高了胃的倒空(75+/-3% ， P【0.05 ) 并且 P 的高剂量(5 mg/kg， i.p ) 禁止它(42+/-11.2% ， P【0.01 ) 。P (1 mg/kg ) 增加了肠的运输(4.2+/-0.3， P【0.05 ) 当更高的剂量(10-20 mg/kg ) 没有效果时。OT (0.8 mg/kg， i.p ) 禁止了胃的倒空(23.5+/-9.8% ， P【0.01 ) 。P (20 mg/kg ) 的禁止的效果(32+/-9.7% ， P【0.05 ) 并且当二化学药品同时被管理时，胃的倒空上的 OT (0.8 mg/kg ) 提高了对方(17+/-9.4% ， P【0.01 ) 。结论：当 P 的高剂量减少了时， P 的低剂量增加了官方补给的活动性它。在怀孕的以后的时期期间，提高了 OT 的血浆水平可以也参予胃肠的抑制。

AIM: To study the dose-dependent of progesterone (P) effect and the interaction between the oxytocin (OT) and P on gastrointestinal motility. METHODS: In order to monitor the gastric emptying and intestinal transit, the SD male rats were intubated via a catheter with normal saline (3 ml/kg) containing Na(2)(51)CrO(4) (0.5 microCi/ml) and 10% charcoal. OT was dissolved into normal saline and P was dissolved into 75% alcohol. RESULTS: Low does of P (1 mg/kg, i.p.) enhanced the gastric emptying (75+/-3%, P<0.05) and high dose of P (5 mg/kg, i.p.) inhibit it (42+/-11.2%, P<0.01). P (1 mg/kg) increased the intestinal transit (4.2+/-0.3, P<0.05) while the higher dose (10-20 mg/kg) had no effect. OT (0.8 mg/kg, i.p.) inhibited the gastric emptying (23.5+/-9.8%, P<0.01). The inhibitory effects of P(20 mg/kg) (32+/-9.7%, P<0.05) and OT (0.8 mg/kg) on gastric emptying enhanced each other when the two chemicals were administrated simultaneously (17+/-9.4%, P<0.01). CONCLUSION: Low dose of P increased GI motility while high dose of P decreased it. During the later period of pregnancy, elevated plasma level of OT may also participate in the gastrointestinal inhibition.