HIF-1α survivin在宫颈上皮内瘤变及宫颈鳞癌中的表达和临床意义

Expression and clinical significance of HIF-1αand survivin in cervical squamous cell carcinoma

目的研究缺氧诱导因子-1α(HIF-1α)和生存素蛋白(survivin)在正常宫颈组织、宫颈上皮内瘤变组织(CIN)及宫颈鳞癌组织中的表达及意义。方法应用免疫组化的方法检测HIF-1α、survivin在宫颈鳞癌标本74例、CIN标本40例、正常宫颈标本24例中的表达情况。分析了两者与宫颈鳞癌病理学分级、临床分期及淋巴结转移的关系。结果 HIF-1α、survivin两种蛋白在正常宫颈组织中不表达,但在CIN组和宫颈鳞癌组中阳性表达率逐渐升高;HIF-1α、survivin阳性表达率与宫颈鳞状细胞癌的病理分级,临床分期,淋巴结转移呈正相关;在宫颈癌组织中HIF-1α与survivin的表达程度呈正相关。结论缺氧诱导因子-1α与survivin的阳性表达对恶性肿瘤的发展起着重要作用,对两个指标的联合检测有助于评估肿瘤的恶性程度及判断预后。

ObjectiveThis paper aimed to study the expression of HIF-1αand survivin in normal cervical tissue, cervical intraepithelial neoplasia（CIN）and cervical squamous cancer tissue.MethodsThe expression levels of HIF-1αand survivin in 74 cases of cervical squamous cancer specimens and 40 cases of cervical intiaepithelial neoplasia specimens and 24 cases of normal cervixs specimens were detected by immunohistochemical methods.Results HIF-1α,surviving is not expressed in normal cervical tissue,but HIF-1α、survivin were positive in cervical cancer, cervical intraepithelial neoplasia;HIF-1α、survivin expression in cervical carcinoma was significantly higher than cervical intraepithelial neoplasia group.HIF-1α、survivin in CIN tissue was significantly higher than the expression of normal cervical mucosa group;HIF-1αand survivin expression in cervical cancer was positively correlated.Conclusion HIF-1αand survivin were collaborative in progression of cervical cancer;Combined detection of the expression of both is useful for evaluating malignancy and predicting prognosis of cervical squamous cancer.