5-溴-4-氯吲哚-3-基-N-乙酰基-β-D-氨基半乳糖苷的合成

Synthesis of 5-Bromo-4-chloroindol-3-yl-N-acetyl-β-D-galactosaminide

首次报道了以β-溴代四乙酰半乳糖和N-乙酰基-5-溴-4-氯-3-羟基吲哚为原料,经过7步化学反应,合成了用于检测白色念珠菌的N-乙酰胺基半乳糖苷酶底物5-溴-4-氯吲哚-3-基-N-乙酰基-β-D-氨基半乳糖苷,并通过核磁、质谱以及生物测定确证其结构。

5-Bromo-4-chloroindol-3-yl-N-acetyl-β-D-galactosaminide, a N-acetamido-β-D-galactoside enzyme substrate for detection of Canidia albicans, was synthesized from β-bromo-2,3,4,6-tetraacetyl galactose and N-acetyl-5- bromo-4-chloro-3-hydroxyindole via 7 steps. Its structure was confirmed by NMR, MS and biological test.