马尼地平磷脂复合物的制备及其溶出度

Preparation and Dissolution of Manidipine Phospholipid Complex

采用单因素与正交设计试验,筛选得到马尼地平磷脂复合物的优化制备工艺为:马尼地平与卵磷脂的投料比为1∶1,将马尼地平浓度为20 mg/ml的甲醇溶液与卵磷脂浓度为100 mg/ml的三氯甲烷溶液按5∶1的比例混合,于40℃反应4 h。采用HPLC法测定药物含量。与原药及其与磷脂物理混合物相比,磷脂复合物溶出度明显提高。

The preparation of manidipine phospholipid complex was optimized by single factor experiment and orthogonal design test. The optimal preparation process was as follows： the weight ratio of manidipine to lecithin was 1 ： 1, the mixture of methanol containing 20 mg/ml of manidipine and chloroform containing 100 mg/ml of lecithin in a volume ratio of 5 ： 1 was incubated at 40 ℃ for 4 h. The drug concentration was determined by HPLC. Compared with the bulk drug and the physical mixture, the dissolution of phospholipid complex was significantly improved.