阿奇霉素治疗活动期强直性脊柱炎的疗效

Effect of azithromycin on ankylosing spondylitis

目的：探讨阿奇霉素治疗活动期强直性脊柱炎的临床疗效。方法：入选活动期强直性脊柱炎64例,治疗组（n=32）予阿奇霉素治疗,对照组（n=32）予非甾体消炎药和免疫抑制剂常规治疗,共观察24周,以疾病活动性指标BASDAI、CRP和ESR作为疗效评价指标。结果：2组活动性指标在治疗第4~20周较治疗前下降（P〈0.05）,在第20~24周有上升趋势,逐渐恢复至治疗前水平。在治疗0~16周观察期间,治疗组活动性指标基本维持在正常水平以下,对照组高于正常水平,差异具有统计学意义（P〈0.05）。结论：阿奇霉素有助于较长时间控制疾病活动,减少疾病复发,药物安全性良好,对临床治疗有一定的指导意义。

Objective To investigate the clinical effect of azithromycin on ankylosing spondylitis （AS）. Methods Sixty-four AS patients with active disease were enrolled in this study. Among them, thirty-two AS patients （treatment group）received Azithromycin treatment at a dose of 0.5 g once a day for a period of 5 - 7 days, and another thirty-two patients receiving conventional treatment served as control（control group）. BASDAI, CRP and ESR served as the disease activity evaluation index. Results Activity indexes in two groups of in the first 4 - 20 weeks of the treatment were decreased compared with those before the treatment （P 〈 0.05）, while a rise was found in the 20 - 24 week and activity indexes gradually returned to pretreatment levels. At 0 - 16 weeks, the disease activity index of treatment group was below normal levels but that of control group was higher than the normal level with significant difference （P 〈 0.05）. Conclusion The treatment of Azithromycin can control the disease activity of AS in the long term, which would be a new proposal in AS treatment.