摘要
ＡＲｅｓｅａｒｃｈＩｎｓｔｉｔｕｔｅｏｆＳｕｒｇｅｒｙ，ＤａｐｉｎｇＨｏｓｐｉｔａｌ，ＴｈｉｒｄＭｉｌｉｔａｒｙＭｅｄｉｃａｌＵｎｉｖｅｒｓｉｔｙ，Ｃｈｏｎｇｑｉｎｇ４０００４２，Ｃｈｉｎａ（ＬｉｕＬＭ，ＣｈｅｎＨＳ，ＨｕＤＹ，ＬｕＲＱ，ＣｈｅｎＹ...
Objective: To elucidate which one of μ, δ and κ opioid
receptors is involved in the cardiovascular depression following traumatic hemorrhagic shock.
Methods: With traumatic hemorrhagic shock rat models, the changes of myocardial and brain
μ, δ and κ opioid receptors and cardiovascular functions and their relationship with
hemodynamic parameters were observed. The effects of δ and κ opioid receptor antagonists
on hemodynamic parameters of traumatic hemorrhagic shock rats were observed. Results:
Following traumatic hemorrhagic shock, the number of myocardial and brain δ and κ opioid
receptors significantly increased, their affinity did not alter, and the increased number of δ and
κ opioid receptors was significantly associated with the decreased hemodynamic parameters.
However, μ opioid receptor in heart and brain did not obviously change. δ opioid receptor
antagonist ICI174,864 and κ opioid receptor antagonist Nor binaltorphimine (50 μg, Icv) could
significantly reverse those decreased hemodynamic parameters. Conclusions: It suggests
that opioid receptors, especially δ and κ opioid receptors are closely related to the
pathogenesis of traumatic hemorrhagic shock, and they play important roles in the depression
of cardiovascular function following traumatic hemorrhagic shock.
