摘要
Elucidation of molecular mechanisms underlying host- pathogen interactions is important for control and treatment of infectious diseases worldwide. Within the last decade, mass spectrometry （MS）-based proteomics has become a powerful and effective approach to better understand complex and dynamic host-pathogen inter- actions at the protein level. Herein we will review the recent progress in proteomic analyses towards bacterial infection of their mammalian host with a particular focus on enteric pathogens. Large-scale studies of dynamic proteomic alterations during infection will be discussed from the perspective of both pathogenic bacteria and host cells.
Elucidation of molecular mechanisms underlying host- pathogen interactions is important for control and treatment of infectious diseases worldwide. Within the last decade, mass spectrometry （MS）-based proteomics has become a powerful and effective approach to better understand complex and dynamic host-pathogen inter- actions at the protein level. Herein we will review the recent progress in proteomic analyses towards bacterial infection of their mammalian host with a particular focus on enteric pathogens. Large-scale studies of dynamic proteomic alterations during infection will be discussed from the perspective of both pathogenic bacteria and host cells.
