中西医联合治疗类风湿关节炎继发骨质疏松症临床效果分析

Treating osteoporosis following rheumatoid arthritis in the integrative medicine

目的:观察中药鹿瓜多肽注射液治疗类风湿关节炎继发骨质疏松症的临床效果。方法:按照随机分配表的方式将收治的80例类风湿关节炎继发骨质疏松症的患者平均分为观察组和对照组,对照组仅给予常规西药甲氨蝶呤、来氟米特进行治疗,观察组在服用甲氨蝶呤等药物的基础上联合中药鹿瓜多肽注射液进行治疗,观察两组患者的治疗效果及血清中白细胞介素-18(IL-18)的含量变化。结果:两组患者经过治疗后,观察组的临床有效率明显高于对照组的临床有效率,差异比较具有统计学意义(P<0.05);观察组患者治疗后血清中白细胞介素-18(IL-18)的含量明显少于治疗前及对照组患者,差异比较具有统计学意义(P<0.05)。结论:中药鹿瓜多肽注射液联合西药甲氨蝶呤等治疗类风湿关节炎继发骨质疏松症,能提高临床治疗疗效、降低血清中IL-18的含量,效果优于单纯的西药治疗,建议推广。

Objective： To observe the Lugua peptide injection for rheumatoid arthritis and osteoporosis. Methods： 80 patients were randomly divided into observation group and control group, the observation group took the Lugua peptide injection plus methotrexate and other drugs, serum interleukin 18 （IL-18） levels change was recorded. Results： The observation group was significantly higher for clinical efficiency （P〈0.05）; Less serum interleukin-18 was in observation （P〈0.05） Conclusion： The TCM Lugua peptide injection combined with Western medicine can improve clinical efficiency, reduce serum IL-18 content.