十全大补汤加减治疗难治性心衰临床分析

Treating refractory heart failure in TCM

目的:探讨十全大补汤加减治疗难治性心衰的临床疗效及安全性。方法:本次研究选择的对象共78例,均为2010年1月-2012年10月我院确诊的各类难治性心衰患者,按入院顺序随机分为治疗组和对照组各39例,两组均给予休息、限盐、利尿、抗感染、吸氧、洋地黄等常规治疗,对照组在此基础上加用硝普纳静脉滴注;治疗组在对照组治疗基础上应用十全大补汤加减治疗。7d后评价两组患者的心功能改善情况、临床症状改善总有效率以及不良反应。结果:治疗组临床治疗有效率92.31%明显高于对照组的79.49%,差异有统计学意义(P<0.05);治疗组在治疗后的心功能指标改善情况均明显优于对照组(P均<0.05),差异均有统计学意义。两组均未见明显不良反应。结论:十全大补汤加减治疗能明显改善RHF患者的心功能,提高生活质量,且毒副作用小,值得临床推广应用。

Objective：To investigate clinical efficacy and safetyof the Shiquan Dabu decoction for refractory heart failure. Methods：78 cases were divided into treatment group and control group 39 cases, both groups were given conventional treatment, the control group was given sodium nitroprusside infusion; the Shiquan Dabu decoction were added in the treatment group. Clinical treatment group had significantly higher efficiency of 92.31% than 79.49%, the difference was statistically significant （P〈0.05）; treatment group improving cardiac function after treatment were significantly better than the control case group （P〈0.05）. Conclusion：the Shiquan Dabu decoction for RHF significantly improved cardiac function, and is worthy of clinical application.