疏肝和胃法对FD患者神经递质表达的影响

Effects of the Shugan Hewei therapy on the change of neurotransmitter in functional dyspesia patients

目的:探讨疏肝和胃法治疗肝胃不和型功能性消化不良患者的疗效及作用机制。方法:90例FD患者随机分为3组:舒胃方组、木香顺气丸组、莫沙比利组,平均每组30例,分别给予相应药物治疗4周。检测患者血清胃泌素、血清NO及胃排空。结果:经舒胃方组治疗后,FD患者胃排空、血清胃泌素改善,血清NO含量明显降低,优于木香顺气丸(P<0.05)。结论:舒胃方是治疗FD的有效方,其作用机制可能是影响FD患者的神经递质,促进胃肠动力。

Objective： To observe the clinical efficacy and mechanism of shuganhewei Therapy on Functional Dyspesia patients. Method： 90 patients were randomly divided into 3 groups： Shuweifang groups, muxiangshunqi pill groups, Mosapride groups. To observe the change of serum GAS, NO and gastric emptdrogs. Result： After treatmented by Shuweifang, the patients was increased in GAS, gastric emptdrogs and delayed in NO, Compared with muxiangshunqi pill group, the curative effect was Statistically significant （P＆lt;0.05）. Conclusion： Shuweifang is effective for the treatment of FD, its mechanism may be affect patients with neurotransmitters, promote gastrointestinal dynamics.