Effects of LPS,PLA_2 and OFR on proton translocation across inner mitochondrial membrane and H^+-ATPase in the liver

Objective To elucidate the effects oflipopolysaccharide(LPS),phospholipase A_2(PLA_2)and oxygen free radical(OFR)onproton transmembrane translocation andH^+-ATPase. Methods The normal rats were sacrificedfor preparetion liver mitochondria and submi-tochondrial particles for experiments in vitro.