小剂量米非司酮与孕三烯酮治疗子宫内膜异位症术后的临床效果

Analysis of the clinical effect of small dose of mifepristone and pregnant three ketene treatment ofendometriosis after operation

目的:观察比较小剂量米非司酮与孕三烯酮治疗子宫内膜异位症术后的临床效果。方法:回顾性分析2005年1月~2014年6月在我院就诊的235例子宫内膜异位症术后病例,随机分为小剂量米非司酮和孕三烯酮治疗两组,通过术后的随访研究,比较术后应用小剂量米非司酮和孕三烯酮的复发率和不良反应发生率。结果:小剂量米非司酮组、孕三烯酮组对子宫内膜异位症术后的缓解和改善症状都有效,有效率均>80%,效果对比P<0.01,差异有统计学意义,小剂量米非司酮组的疗效优于孕三烯酮组。不良反应方面两组均有阴道少量出血,小剂量米非司酮组少于孕三烯酮组(P<0.01),差异有统计学意义。皮肤黏膜变化、胃肠道反应、肝功能异常经统计学处理P>0.05,两组差异均无统计学意义。结论:小剂量米非司酮和孕三烯酮治疗子宫内膜异位症术后,能显著降低该病复发率,米非司酮可使异位子宫内膜萎缩、疼痛缓解,对炎性因子有一定抑制作用。比较两组治疗结果,小剂量米非司酮组的疗效优于孕三烯酮组^([3]),小剂量米非司酮组的不良反应少于孕三烯酮组^([4]),更易被患者接受,也是最经济可行的。因此,小剂量米非司酮可作为治疗子宫内膜异位症的临床一线药物使用。

Objective： Comparison Of the clinncal effect of small dose of mifeprisone and pregnant three ketene treatment of endometriosis after operation.Methods： A retrospective analysis of 2005 Jauaary to 2014 June in ourhospital 235 cases of endomertosis postoperotive patients,divided into low dose mifepristone and pregnant three ketene treatment group two,through the analysis of follow up study of 235 case of patienta with pelcic endometriosis after I institute.Theincidence of low dose mifepritone and pregnant three ketene campared postopercitive recurrence rate and side reaction. Results： A low dose mifepritone group, pregnant three ketene two groups onpostoperative endometriosis patients ease and improve the symptomswere effective, the effective rate was 〉80%. the effect of contrast on the P〈0.01, there was significant difference between two groups, small dose of mifepristone group curative effect surpasses the pregnant threeketene group. The side reaction, a small amount of vaginal bleeding： （P 〈O.01）with small dose of mifepristone group less than pregnant threeketene group two groups, there was significant difference between. The change of skin mucosa, gastrointestinal reaction, liver function abnormalities were P〈0.05, the two groups showed no significant differences. Conclusion： Low dose mifepristone and pregnant three ketene treatment of pelvieendometriosis postoperative patients, cansignificarifly reduce the incidence ofendometriosis.Mifepristone can cause the atrophy of eetopic endometrium,pain feller, and hasinhibitory effects oninflammatory factors.The eomparisonresult low dose of mifepristone group euiative effect surpasses the prengnant three ketene group ,the same side effects of low dose mifepristone is lessthan pregnant threee retene group ,moreeasily accepted by the patients,from the econnmics point of view,which is the most economical and feasible.So the low dose mifepristone can be use as the fist-line drugs for the treatment of endometriosis disease.