肝硬化患者合并医院感染的临床特征分析

Analysis the clinical characteristics of nosocomial infections in patients with liver cirrhosis

目的探讨肝硬化合并医院感染患者的临床特征。方法选择50例肝硬化合并医院感染患者作为观察组,按照1∶1比例选择50例肝硬化未合并医院感染患者作为对照组,统计分析医院感染分布;比较2组患者相关因素的差异;观察医院感染对预后的影响。结果医院感染构成分布为:呼吸系统感染14例(28.00%)、自发性腹膜炎13例(26.00%)、胆管系统感染10例(20.00%)、肠道感染6例(12.00%)、泌尿系感染4例(8.00%)、皮肤及软组织及其他感染3例(6.00%)。观察组患者年龄≥60岁34.00%、Child-Pugh分级C级62.00%、实施侵入性操作38.00%、预防应用抗生素34.00%,高于对照组的10.00%,20.00%,20.00%,18.00%(P<0.05),是导致医院感染的危险因素。观察组患者平均住院时间(36.18±12.08)d,死亡10例(20.00%),高于对照组的(19.27±4.23)d、2例(4.00%)(P<0.05)。结论肝硬化患者由于多种因素的存在常可导致医院感染发生,对预后有不良影响,应实施针对性措施以预防及减少医院感染的发生。

Objective To explore the chnical characteristics of the patients hospital infection complicated with liver cirrhosis. Methods 50 cases of cirrhosis with Choice of hospital infection patients as the observation group, according to the 1：1 proportional selection of 50 cases of liver cirrhosis with hospital infection for the patients as control group, statistical analysis of hospital infection distribution;difference between the two groups of patients with related factors of prognosis;influence infection in hospital. Results the nosocomial infection constitutes.Distribution： 14 cases of respiratory system infection （28%）, 13 cases of spontaneous bacterial peritonitis （26%）, 10 cases of infection of biliary system （20%）,6 cases of intestinal infection （12%）,urinary tract infection in 4 cases （8%）,skin and soft tissue infection and the other 3 cases （6%）.The observation group patients 60 years of age or older in 34%, Child-Pugh class C 62%, the implementation of invasive operation38%, use of antibiotics 34% higher than that of the control group 10%, 20% ,20%, 18% （P〈0.05） ,is the cause of the risk factors of hospital infection.Patients in the observation group the average hospitalization time （36.18 ＋ 12.08） day, 10 cases died （20%） was higher than that of control group （19.27 ＋ 4.23） days,2 cases （4%）（P〈0.05）.Conclusion Patients with cirrhosis due to a wide variety of factors exist often leads to the occurrence of hospital infection,have adverse effects on prognosis,should be the implementation of targeted measures to prevent and reduce the occurrence of hospital infection.