中华秋海棠对大鼠慢性盆腔炎的作用

Influence of Effective Parts of Begonia grandis sinensis on Chronic Pelvic Inflammatory Disease Rats

目的:通过研究中华秋海棠块茎正丁醇、乙酸乙酯提取物对大鼠慢性盆腔炎模型的影响,探讨其作用效果及初步机制。方法:除假手术组(只手术不造模)外,其余大鼠建立慢性盆腔炎模型(机械损伤加混合菌感染),造模7 d后随机分为模型组、正丁醇提取物高和低剂量组、乙酸乙酯提取物高和低剂量组、阳性组、假手术组,共7组,每组8只,连续给药14 d后(假手术及模型组同法灌胃水)检测子宫肿胀度、子宫病理组织学、血清白细胞介素-2(IL-2)和IL-6水平。结果:正丁醇和乙酸乙酯提取物均能明显抑制子宫肿胀、改善子宫炎症程度,将炎症大鼠IL-2,IL-6水平恢复至正常水平。结论:中华秋海棠能有效减轻大鼠子宫炎症,其作用机制与抑制炎性因子有关。

Objective： To investigate effect and mechanism of Begonia grandis sinensis through studying effective actions of two extracts on chronic pelvic inflammatory disease（CPID） rats. Method： CPID rats were separated to 7 groups and 8 rats in each group. Sham operation group only accepted surgery no modeling,while other rats were treated by mechanical damage and mixed infection and divided into the mode group,butanol high and low groups,ethyl acetate high and low groups and positive group. After treatment of administration for 14 days（sham operation group and model group only treated by water as negative control）,uterine swelling degree,uterine specimen,level of interleukin-2（IL-2） and IL-6 of all the groups were detected. Result： These two extracts of B. grandis sinensis could inhibit uterine swelling,improve degree of inflammation in the uterus,restore concentrations of IL-2 and IL-6 to normal level in CPID rats. Conclusion： B. grandis sinensis can effectively reduce uterine inflammation of rats,its mechanism is relative with inhibition of inflammatory factors.