阿托伐他汀联合贝那普利治疗老年糖尿病肾病的效果观察

Effect observation of atorvastatin combined with benazepril in the treatment of gerontism patients with diabetic nephropathy

目的：探讨阿托伐他汀联合贝那普利治疗老年糖尿病肾病的疗效。方法将2012年1月-2014年5月本院收治的104例老年糖尿病肾病患者随机分为治疗组和对照组（各52例），对照组在常规综合治疗的基础上给予贝那普利治疗，治疗组在对照组治疗的基础上给予阿托伐他汀治疗。结果两组患者治疗后24 h尿蛋白定量、BUN及SCr较治疗前均降低（P〈0.05）；治疗组治疗后的24 h尿蛋白定量、SCr降低程度较对照组降低更为明显（P〈0.05）；治疗组总有效率为86.5%，明显优于对照组的61.5%（P〈0.05）。结论阿托伐他汀联合贝那普利治疗老年糖尿病肾病疗效显著，不良反应少，值得临床推广。

Objective To investigate the curative effect of atorvastatin combined with benazepril in the treatment of gerontism patients with diabetic nephropathy. Methods 104 gerontism patients with diabetic nephropathy in our hospi-tal from January 2012 to May 2014 were selected,and were randomly divided into treatment group and control group, with 52 cases in each group.Benazepril was taken to control group on the basis of routine treatment,atorvastatin was tak-en to treatment group on the basis of the treatment for control group. Results After being treated,quantitation of protein-uria in 24 h urine sample,BUN and SCr was lower than that before the treatment respectively （P〈0.05）.Quantitation of proteinuria in 24 h urine sample and SCr of treatment group decreased more significantly than that in control group（P〈0.05）.The total efficiency of treatment group was 86.5%,more superior than 61.5%of control group（P〈0.05）. Conclusion Atorvastatin combined with benazepril is effective in the treatment of gerontism patients with diabetic nephropathy,with fewer adverse reactions,which is worthy of promotion.