中药单体及提取物的神经保护作用：Nrf2信号通路研究进展

Neuroprotective effect of Chinese herbal monomers and extracts via activation of Nrf2 signal pathway

背景:大量数据表明中药单体具有神经保护作用,可以提高脑神经系统损伤患者生活质量。Nrf信号通路在出血性与缺血性卒中具有神经保护作用,它是通过无毒的天然或合成的中药发挥神经系统修复作用,但是目前很少对这方面中药进行系统报道。目的:从Nrf2信号通路的角度对脑卒中后神经损伤发挥作用的中医单体进行综述。方法:第一作者计算机检索中国知网,维普,MEDLINE和Pub Med数据库。检索词是:"Nrf2、ARE、脑卒中、中药、神经保护"和"Nrf2,ARE,Stroke,Traditional Chinese Medicine,Neuroprotection"。检索语言设置为中文和英文。探讨Nrf2和神经保护的研究进展及中药单体的脑卒中后神经保护作用。结果与结论:共检索到85文章,根据纳入和排除标准,对文献进行筛选,最终共纳入46篇。结果表明,多种中药单体可以通过Nrf2通路发挥神经保护作用。中药单体研究涉及有机酸、酚类、皂甙、黄酮类、萜类、生物碱类和其他单一或复合成分。中药对脑卒中后神经损伤有明确修复作用,但此类中药缺乏规律性,它仍然需要扩大数据和进一步的研究作为基础。

Abstract BACKGROUND： Large amounts of data have shown that Chinese herbal monomer has a neuroprotective effect, and can improve the quality of life in stroke patients with cerebral nervous system injury. Nuclear-factor-erythroid 2-related （Nrf2） factor has neuroprotective effect on hemorrhagic stroke and ischemic stroke, which is an important way to reverse the damage of nervous system through the natural non-toxic Chinese herbs or composition, but it is rarely reported systemicaly. OBJECTIVE：To summarize the neuroprotective effect of Chinese herbal monomersvia the Nrf2 signal pathway in stroke patients. METHODS：The first author retrieved the CNKI, VIP, Medline, and PubMed databases by computer. The keywords were “Nrf2, ARE, stroke, traditional Chinese medicine, neuroprotection” in Chinese and English,respectively. Articles concerning the neuroprotective role of Chinese herbal monomervia Nrf2 were analyzed and discussed. RESULTS AND CONCLUSION： Totaly 85 articles were retrieved. According to the inclusion and exclusion criteria, 46 articles were included in result analysis. The results show that a variety of monomers can exert neuroprotective effectsvia the Nrf2 pathway. Chinese herbal monomers include organic acids, phenols, saponins, terpenes, flavonoids, alkaloids, and other single or composite components. Traditional Chinese medicine has the clear neuroprotective effect after stroke, but it is lack of regularity, and it is stil need to expand the data and further research as the basis.