组织工程骨修复骨缺损的稳定性：材料降解与新骨形成

Stability of tissue engineering bone in the repair of bone defects: material degradation and bone formation

背景:支架材料是组织工程骨重要的组成部分,理想材料的生物降解速度应与新骨替代生成速度一致,最终材料完全降解被新骨取代,以达到长期稳定的目的。目的:综述现有不同类型支架材料的降解及其与新骨形成的关系。方法:由第一作者从Pub Med数据库及CNKI数据库中,以"tissue engineering bone,composite scaffold,scaffold degradation;组织工程骨,支架材料,生物降解"为主题词检索1996年1月至2013年12月间发表的文献,选择与支架材料降解及其与新骨形成关系的相关文献。结果与结论:目前已有多种有机、无机及有机-无机复合材料作为支架材料,近年来重点是对无机材料及有机-无机材料复合物开展研究。体内外实验结果表明,各类材料具备不同的特性且各有优劣。有机材料降解速率相对较慢,无机材料虽能完全降解,但机械性能不够,对于复合材料仍需要开展进一步的动物实验和临床研究。

BACKGROUND：Scaffold materials are the important part of tissue engineering bone, and the ideal biodegradation speed of the scaffold materials can be in accordance with the regeneration speed of bone formation in order to achieve a long-term stability. OBJECTIVE：To summarize the biodegradability of different types of currently available scaffold materials and its relationship with bone formation. METHODS：The PubMed and CNKI database were searched by the first author using the key words of “tissue engineering bone, composite scaffold, scaffold degradation” in English and Chinese for articles addressing biodegradability of scaffold materials and its relationship with bone formation published during January 1996 and December 2013. RESULTS AND CONCLUSION：Many scaffold materials under organic, inorganic and organic-inorganic categories have been available and the current studies focus on inorganic materials and organic-inorganic composite materials.In vivo andin vitro studies indicate the different characteristics and relative merits of these scaffold materials. Organic materials have a relatively slow degradation rate while inorganic materials can completely degrade but have an insufficient mechanical property. For organic-inorganic composite materials, further studies are needed.