急性胰腺炎肝损伤的研究进展

Research progress on liver injury in acute pancreatitis

本文根据大量研究成果,阐明急性胰腺炎肝损伤是局部炎症向全身反应进展的标志,着重说明了Kupffer细胞以及各种细胞因子、巨噬细胞移动抑制因子（MIF）是急性胰腺炎（AP）并发肝损伤病理进展的关键因素.鉴于目前对急性胰腺炎肝损伤的病理机制尚无统一确切结论,开展对MIF、细胞因子对AP肝损伤的相关细胞信号调控机制研究,不仅能发现相应的干预靶点,还能为临床治疗提供新思路.本文分别从病因、病理和诊断三方面对急性胰腺炎并发肝损伤的研究进展进行综述.

Considerable clinical and experimental evidence supports that liver injury in acute pancreatitis （AP） is a sign for the potential progression to systemic inflammatory reaction.The Kupffer cells,various cytokines and macrophage migration inhibitory factor （MIF） play important roles in the pathogenesis of AP associated liver injury.However,the specific molecular mechanism of the liver damage remains uncertain.Therefore,efforts should be made to clarify the regulatory mechanism and related cell signaling disorders of liver injury in AP,which could not only identify novel therapeutic targets,but also provide new insight into improving the clinical treatment.Here our review discusses the recent research progress on the etiology,pathology and diagnosis and treatments of liver injury in AP.