肠道病毒71型复制周期研究进展

Recent progress in the replication cycle of enterovirus 71

人类肠道病毒71型（enterovirus 71,EV71）属于小RNA病毒科肠道病毒属。自1969年首次从美国加利福尼亚1名患有中枢神经系统疾病的手足口病婴儿粪便样本中分离出EV71病毒以来,手足口病在世界各地曾多次出现大流行,多发于5岁以下儿童,可引起发热和口腔、手、足部的溃疡或斑疹等症状。少数患儿可引起心肌炎、肺水肿、无菌性脑膜脑炎等并发症。如果病情发展快,导致重症患儿死亡[1]。

Enterovirus 71（EV71）is one of the primary pathogenic agents that cause hand,foot,and mouth disease（HFMD）mainly among young children.As the disease progresses,the virus may lead to severe neurological disorders with high mortality and disability rates.There are currently no effective prevention and treatment strategies to combat EV71 infection.Investigating molecular mechanisms involved in EV71 replication cycle and cell infection could facilitate the progress for the design of new drugs and vaccines against this virus.This article reviews the recent advances in the replication cycle of EV71.