摘要
目的研究协同刺激分子B7-H1在自发性流产患者的表达及其生物学意义。方法 ELISA法检测正常未孕者(A组,52例)、正常妊娠者(B组,49例)、自发性流产患者(C组,52例)和自发性流产后再妊娠者(D组,17例)血清可溶性B7-H1(sB7-H1)的含量。免疫组化法检测正常妊娠行人工流产术患者(E组,20例)和自发性流产患者(F组,21例)绒毛膜和蜕膜中B7-H1的表达。结果 A、B、C、D组血清sB7-H1含量无统计学差异(P>0.05)。E组蜕膜中B7-H1的表达高于F组(P<0.05),但两组绒毛膜中B7-H1的表达无统计学差异(P>0.05)。结论 B7-H1参与了正常妊娠过程;其异常表达对自发性流产的发生有重要意义。
Objective To study the expression and biological significance of costimulatory molecule B7-H1 in the patients with spontaneous abortion .Methods Serum levels of soluble B7-H1 (sB7-H1) in nonfertile women (group A ,52 cases) ,normal pregnancy women (group B ,49 cases) , patients with spontaneous abortion (group C ,52 cases ) and pregnancy women with a history of spontaneous abortion(group D ,17 cases) were determined by ELISA .The expressions of B7-H1 in chorion and decidua tissues of normal pregnancy women underwent artificial abortion (group E , 20 cases) and of patients with spontaneous abortion (group F ,21 cases ) were detected by immunohistochemistry .Results There was no significant difference in serum content of sB7-H1 among groups of A ,B ,C and D(P〉0 .05) .The expression of B7-H1 in decidua tissues was higher in group E than that in group F (P〈0 .05) ,which in chorion tissues showed no significant difference between two groups(P〉0 .05) .Conclusion B7-H1 participates in the process of normal pregnancy and abnormal expression of B7-H1 has an important significance in the occurrence of spontaneous abortion .
出处
《江苏医药》
CAS
2015年第8期926-928,F0003,共4页
Jiangsu Medical Journal
关键词
协同刺激分子
自发性流产
妊娠
Costimulatory molecule
Spontaneous abortion
Pregnancy