昆明地区绝经女性日照量与血清VitD水平及骨密度之间的相关性研究

The correlation between sunlight exposure,serum vitamin D level,and bone mineral density in postmenopausal women in Kunming

目的研究昆明地区绝经女性日照量与血清25（OH）D水平及骨密度之间的关系,以加强高原人群骨质疏松症的防治。方法随机选取除外继发性骨质疏松症的90名年龄超过45岁的绝经女性,以每天日照量分3组,1组：〈30 min/d;2组：30-60 min/d;3组：〉60 min/d。用Elisa法检测血清25（OH）D浓度,用双能X线吸收测定法（DXA）测定腰1至腰4椎体及双侧股骨颈骨密度。比较3组之间的差异。结果 3组之间T值有差异（P〈0.05）,所测骨密度以骨量减少为主,骨质疏松检出率为34.81%;日照量与T值相关性不大。3组之间25（OH）D浓度有差异（P〈0.05）,有48.89%的血清25（OH）D浓度处于最佳范围水平;日照量与25（OH）D浓度相关性较大。结论日光照射可促进25（OH）D生成,日照30~60 min/d对高海拔、低度缺氧所致骨量丢失有弥补作用。日照量对骨密度起不到决定性作用。

Objective This study explores the relations between the sunlight exposure, serum vitamin D level, and bone density in postmenopausal women, in order to strengthen the prevention and treatment of osteoporosis in people residing in plateau area. Methods Ninety postmenopausal women aging over 45 years without secondary osteoporosis were randomly selected. They were divided into 3 groups with varied daily sunlight exposure： Group A with daily exposure less than 30 min, Group B with 30-60 min, and Group C with more than 60 min. Serum 25 （OH）D level was tested using ELISA method. Bone mineral density of the lumbar vertebra L1-4 and bilateral femoral necks was tested using a dual-energy X-ray absorptiometry （DXA）. The difference among the 3 groups was compared. Results The difference of T values among the 3 groups was significant （P 〈 0. 05）. Bone mineral density results showed mainly bone mass loss. The osteoporosis rate determined in the selected 90 subjects was 34. 81%. The correlation between sunlight and the T value was not significant. The difference of 25 （OH） D concentration among the 3 groups existed （ P 〈 0.05 ）. 48.89% of the subjects were found in the optimal serum 25 （OH）D range. The correlation between the sunlight amount and 25 （OH）D concentration was obvious. Conclusion Sunlight can promote 25 （OH）D level. Exposure time of 30-60 min/d can compensate the high-altitude and low degree of hypoxia-induced bone loss. Sunlight does not achieve a decisive role in bone mineral density.