PI3K/Akt信号通路在骨质疏松病理过程中的作用

Effect of PI3K/Akt pathway on the pathological development of osteoporosis

磷脂酰肌醇三激酶/蛋白激酶B(PI3K/Akt)信号通路是调节细胞增殖、分化、存活、迁移和代谢过程的最为重要的一个信号通路。越来越多的证据表明,骨组织中的许多信号分子能够选择性激活PI3K/Akt信号通路的相关基因,通过调控成骨细胞和破骨细胞的活动,破坏骨重建过程中骨形成与骨吸收的动态平衡,在骨质疏松的发生和发展中扮演着非常重要的角色。

The phosphoinositide 3-kinase and Akt （PI3K/Akt） signaling pathway is the vital pathway responsible for the regulation of the process of cellular proliferation, differentiation, survival, migration, and metabolism. Increasing evidences highlight a pivotal role of diverse proteins in the bone tissue in the development and progression of osteoporosis. These molecules exert an influence in specific activation of gene expression related to PL3K/Akt signaling, contributing to unbalance of bone formation and bone resorption in the process of remodeling via regulation of activities of both osteoblasts and osteoclasts.