严重意识障碍患者康复过程EEG非线性特征与CRS-R评分相关性分析与可视化表征

Correlation Analysis of Nonlinear Characteristics in EEG with CRS-R Score and Visual Characterization of Rehabilitation Process in DOC Patients

研究严重意识障碍患者意识康复过程脑电非线性特征与行为学意识量表CRS-R评分之间的相关性,并将非线性特征用于脑功能的可视化表征,为建立脑电非线性特征用于评估严重意识障碍患者意识康复过程提供电生理学依据。采集严重意识障碍患者(最小意识状态(MCS)10例和植物状态(VS)8例)意识康复过程中前后两次安静状态的脑电数据,计算近似熵、样本熵、排列熵和复杂度LZC等4种脑电非线性特征,对比分析非线性特征变化与CRS-R评分变化之间的相关性,并利用脑电地形图将近似熵非线性特征进行可视化表征。结果表明,MCS组和VS组CRS-R评分变化均为显著差异(P<0.01);MCS组的近似熵和复杂度LZC变化为显著差异(P<0.05),而VS组只有近似熵变化为显著差异(P<0.05);MCS组近似熵、复杂度LZC的变化与CRS-R评分变化的相关系数分别为0.851和0.693,呈显著正相关,VS组只有近似熵变化与CRS-R评分变化为显著正相关,相关系数为0.778;近似熵用于患者脑地形图可视化表征具有较好的效果。近似熵非线性特征用于评估严重意识障碍患者的意识康复过程具有一定的可行性。

To provide an electrophysiology judgment method for evaluating the rehabilitation process of severe disorders of consciousness （DOC） patients,the correlation between EEG nonlinear characteristics and CRS-R score was studied,and a visual characterization method was developed.The EEG data （acquired twice in a quiet state） of awareness patient＇ s （minimally conscious state,MCS,10 and vegetative state,VS,8） rehabilitation process were collected,nonlinear characteristics （approximate entropy,sample entropy,permutation entropy and complexity LZC） were calculated to compare the changes between nonlinear characteristics and CRS-R score,and then were used to brain mapping for visual characterization.The CRS-R score changes significantly both for MCS and VS patients （P ＜ 0.01）.Approximate entropy and complexity LZC changes significantly for MCS patients （P ＜ 0.05）,while only approximate entropy changes significantly for VS patients （P ＜ 0.05）.There has significantly positive correlation of score changes between CRS-R and nonlinear characteristics （approximate entropy for both MCS and VS,complexity LZC for MCS only）,the correlation coefficients were calculated,0.851 and 0.693 for MCS （approximate entropy and complexity LZC）,and 0.778 for VS （approximate entropy）.Approximate entropy can be used to visualize patient＇ s brain function mapping.Approximate entropy could be used as a potential method to evaluate the rehabilitation process for patients with awareness.