期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

氧化应激及抗氧化物在年龄相关性黄斑变性中的作用 被引量：13

Roles of oxidative stress and antioxidants in age related macular degeneration
下载PDF
导出
摘要 氧化应激反应直接参与了年龄相关性黄斑变性(aged-related macular degeneration,AMD)的病理过程,其中以抗氧化剂、抗氧化酶为主组成的抗氧化防御系统对预防AMD的发生发展极为重要。现就氧化应激及抗氧化物在AMD发生发展及防护中的作用机制作一综述。 Oxidative stress directly participates in the pathological process of aged- related macular degeneration（AMD）. Therefore,antioxidant system including antioxida- nts and antixodatnt enzymes are crucial to the development and progression of AMD. This article reviews the mechanism and roles of oxidative stress and antioxidants on AMD development and protection.
作者 俞永珍 邹秀兰 邹玉平
机构地区 广州军区广州总医院眼科 广州中医药大学
出处 《眼科新进展》 CAS 北大核心 2015年第5期489-492,共4页 Recent Advances in Ophthalmology
基金 广东省科技计划项目(编号:2011B031800202 2012B031-800419) 广东省自然科学基金项目(编号:S2013010012045)~~
关键词 年龄相关性黄斑变性 氧化应激 抗氧化物 活性氧 age related macular degeneration oxidative stress antioxidants reac-tive oxygen species
分类号 R774.5 [医药卫生—眼科]
  • 相关文献

参考文献37

  • 1Lu L, Hackett SF, Mincey A, Lai H, Campochiaro B. Effects of different types of oxidative stress in RPE cells[J]. J Cell Physi- ol,2005,205( 1 ) :119-125.
  • 2Dorey CK, Wu G, Ebenstein D, Garsd A, Weiter JJ. Cell loss in the aging retina. Relationship to lipofuscin accumulation and macular degeneration [ J] . Invest Ophthalmol Vis Sci, 1989 , 30 (8) :1691-1699.
  • 3Chiba Y, Shimada A, Kumagai N, Yoshikawa K, Ishii S, Furukawa A,et al. The senescence-accelerated mouse ( SAM) :A higher oxidative stress and age-dependent degenerative diseases model [ J] . Neurcchem. Res, 2009 ,34 ( 4 ) : 679-687 .
  • 4Klein LR,MacLeish PR, Wiesel TN. Immunolabelling by a newt retinal pigment epithelium antibody during retinal development and regeneration [ J]. J Comp Neurol , 1990 ,293 (3) :331-339.
  • 5Chen H, Lukas TJ, Du N , Suyeoka G, Neufeld AH. Dysfunction of the retinal pigment epithelium with age: Increased iron decreases phagocytosis and lysosomal activity [ J] . Invest Ophthalmol Vis Sci,2009 ,50( 4) : 1895-1902.
  • 6Cui H, Kong Y, Zhang H. Oxidative stress, mitochondrial dysfunction,and aging [ J]. J Signal Transduct,2012 ,2012 :646354.
  • 7Jin GF, Hurst JS, Godley BF. Rod outer segments mediate mitochondrial DNA damage and apoptosis in human retinal pigment epithelium[J]. Curr Eye Res ,2001,23 (1) : 11-19.
  • 8Desler C, Marcker ML, Singh KK, Rasmussen LJ. The importance of mitochondrial DNA in aging and cancer [ J]. J Aging Res, 2011,2011 :407536.
  • 9Justilien V, Pang JJ , Renganathan K, Zhan X, Crabb JW , Kim SR, et ol. SOD2 knockdown mouse model of early AMD [ J] . Invest Ophthalmol Vis Sci,2007 ,48 (10) :4407-4420.
  • 10Ham WT Jr, Ruffolo JJ Jr, Mueller HA, Claeke AM, Moon ME.Histologic analysis of photochemical lesions produced in rhesus retina by short-wave-length light [J]. Invest Ophthalmol Vis Sci, 1978,17 (10) : 1029-1035.

同被引文献101

引证文献13

二级引证文献42

眼科新进展
2015年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部