期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

甲状腺相关眼病动物模型的构建 被引量：1

Review of animal models for thyroid associated ophthalmopathy
下载PDF
导出
摘要 甲状腺相关性眼病(TAO)是一种器官特异性自身免疫性疾病,居成人眼眶病发病率之首,其确切病因和发病机制至今不明确。 Thyroid associated ophthalmopathy （ TAO） is an autoimmune disorder and the most common orbitopathy in adults.The exact etiologies and mechanisms of pathogenesis are still not fully understood.It is important to establish an animal model for TAO in order to investigate the disease mechanism and to explore potential treatments.
作者 丁鲁娜 涂云海 张蛟 吴文灿
机构地区 温州医科大学附属眼视光医院
出处 《临床眼科杂志》 2015年第2期186-188,共3页 Journal of Clinical Ophthalmology
基金 浙江省自然科学基金(LQ12H12004)
关键词 甲状腺相关性眼病 动物模型 Thyroid associated ophthalmopathy Animal model
分类号 R771.3 [医药卫生—眼科]
  • 相关文献

参考文献22

  • 1Balm RS. Graves'ophthalmopathy. New England Journal d Medi- cine, 2010, 362:726-738.
  • 2罗清礼.甲状腺相关性眼病.北京:人民卫生出版社.2003:190-191.
  • 3Weetman AP. Graves'disease. New England Journal of Medicine, 2000, 343:1236-1248.
  • 4Smelser GK. Experimental production of exophthalmos xesembling that found in Graves disease. Experimental Biology and Medicine, 1936,35 : 128-130.
  • 5Costagliola S, Alcalde L, Tonacchera M, et al. Induction of thy- nmopin receptor (TSH-R) autoantibodies and thyroiditis in mice immunized with the reombinant TSH-R. Biochemical and bio- physical n~search ,1994,199:1027-1034.
  • 6Costagliola S, Many MC, Stalmans-Falys M, et al. The autoim- mune ~.sponse induced by immunising female mice with recombi- nant human thyrotropin receptor varies with the genetic back- ground. Molecular and cellular endocrinology, 1995, 115: 199- 206.
  • 7Costagliola S, Rodien P, Many MC, et al. Genetic immunization against the human thyrotropin receptor causes thyroiditis and allows pnxluction of monoclonal antibodies recognizing the native recep- tor. The Journal of Immunology, 1998,160 : 1458-1465.
  • 8Costagliola $, Many MC, Denef .IF, et al. Genetic immunition of outbred mice with thyrotropin receptor cDNA provides a model of Graves' disease. Journal of Clinical Investigation, 2000, 105 : 803-811.
  • 9Pichurin P, Yah XM, Farilla L, ct al. Naked TSH receptor DNAvaccination: a Thl T cell response in which interferon g production rather than antibody dominates the immune response in mice. En- docrinology,2001,142:3530-2536.
  • 10Rao PV, Watson PF, Weetman AP, et al. Contrasting activities of thyrotropin receptor antibodies in experimental models of Graves' disease induced by injection d tmrmfeeted fibroblasts or deoxyribonucleic acid vaccination. Endocrinology, 2003, 144: 260-266.

二级参考文献21

  • 1詹升华,张徽,刘纯.pcDNA3.1/hTSHR真核表达载体的构建及其在COS-7细胞中的表达[J].细胞与分子免疫学杂志,2004,20(4):390-393. 被引量：6
  • 2沈绍群,李林.甲状腺机能减退症动物模型研究进展[J].华西医学,2006,21(2):416-417. 被引量：7
  • 3Klein I,Ojamaa K.Thyroid hormone:targeting the vascular smooth muscle cell[J].Circ Res,2001 Feb 16,88(3):260-264.
  • 4Fukuyama K,Ichiki T,Takeda K,et al.Downregulation of Vascular Angiotensin II Type 1 Receptor by Thyroid Hormone[J].Hypertension,2003,41:598-603.
  • 5Serafino F,Emiliano A.Palmieri,et al.Effects of Thyroid Hormone on the Cardiovascular System[J].Recent Progress in Hormone Research,2004,59:31-50.
  • 6Marchant C,Brown L,Sernia C.Renin-angiotensin system in thyroid dysfunction in rats[J].Cardiovasc Pharmacol,1993,22:449-455.
  • 7Raffaele N,Bernadette B,Vincenzo G,et al.Impact of Hyperthyroidism and Its Correction on Vascular Reactivity in Humans[J].Circulation,2001,104:3076-3080.
  • 8Kiselev VI,Treshutin VA.Role of the blood kallikrein-kinin system in activating hemodynamic effects induced by L-thyroxine[J].Probl Endokrinol(Mosk),1982,28(1):78-81.
  • 9Hu LW,Benvenuti LA,Liberti EA,et al.Thyroxineinduced cardiac hypertrophy:influence of adrenergic nervous system versus renin-angiotensin system on myocyte remodeling[J].Physiol Regul Integr Comp Physiol,2003,285:R1473-R1480.
  • 10Marcocci C, Marino M, Rocchi R. Novel aspects of immunosuppressive and radiotherapy management of Graves' ophthalmopathy [ J ]. J Endocrinol Invest,2004, 27 : 272 - 280.

共引文献19

同被引文献7

引证文献1

临床眼科杂志
2015年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部