丹参多酚酸盐注射液对实验性结肠炎小鼠血清脂肪因子水平的影响

Effect of Salvianolic injection on the adipokines of mice with experimental colitis

目的通过测试血清脂肪因子水平,了解丹参多酚酸盐是否对脂肪因子产生影响,进一步探讨丹参多酚酸盐治疗实验性结肠炎的可能机制。方法选用雄性BALB/C小鼠30只随机分为对照组、模型组、丹参多酚酸盐干预组,饮用5%DSS造模,14 d后检测相应指标。结果与模型组比较,干预组的肠道炎症明显减轻(P<0.01)。模型组小鼠血清瘦素、趋化素均较对照组升高(P<0.05),但脂联素降低(P<0.05);干预组仅血清瘦素较模型组低(P<0.05),脂联素和趋化素与模型组相比,差异无统计学意义(P>0.05)。结论丹参多酚酸盐对小鼠实验性结肠炎具有一定的治疗作用,其机制之一可能是调节脂肪因子。

Objective To observe the treatment effect of Salvianolic injection on the adipokines of mice with experi-mental colitis and investigate the possible mechanism of it .Methods Thirty BALB/C mice were randomly divided into control group, modle group and interventional group .Colitis was induced by 5%DSS oral administration for 7 d.14 d later, indices were determined .Results Treatment of mice with Salvianolic injection could reduce colon inflammation induced by DSS （ P〈0 .01 ） .Serum chemerin , leptin were higher in the model group than those in the control group （ P〈0.05）, but adiponectin decreased （P〈0.05）.Leptin decreased in the interventional group （P〈0.05）, while the changes of chemerin and adiponectin had no statistically significance （ P〉0 .05 ） .Conclusion Salvianolic injection have some theroputic effect on colitis in mice ,and the mechanism maybe due to its regulation effcet on adipokines .