摘要
目的通过测试血清脂肪因子水平,了解丹参多酚酸盐是否对脂肪因子产生影响,进一步探讨丹参多酚酸盐治疗实验性结肠炎的可能机制。方法选用雄性BALB/C小鼠30只随机分为对照组、模型组、丹参多酚酸盐干预组,饮用5%DSS造模,14 d后检测相应指标。结果与模型组比较,干预组的肠道炎症明显减轻(P<0.01)。模型组小鼠血清瘦素、趋化素均较对照组升高(P<0.05),但脂联素降低(P<0.05);干预组仅血清瘦素较模型组低(P<0.05),脂联素和趋化素与模型组相比,差异无统计学意义(P>0.05)。结论丹参多酚酸盐对小鼠实验性结肠炎具有一定的治疗作用,其机制之一可能是调节脂肪因子。
Objective To observe the treatment effect of Salvianolic injection on the adipokines of mice with experi-mental colitis and investigate the possible mechanism of it .Methods Thirty BALB/C mice were randomly divided into control group, modle group and interventional group .Colitis was induced by 5%DSS oral administration for 7 d.14 d later, indices were determined .Results Treatment of mice with Salvianolic injection could reduce colon inflammation induced by DSS ( P〈0 .01 ) .Serum chemerin , leptin were higher in the model group than those in the control group ( P〈0.05), but adiponectin decreased (P〈0.05).Leptin decreased in the interventional group (P〈0.05), while the changes of chemerin and adiponectin had no statistically significance ( P〉0 .05 ) .Conclusion Salvianolic injection have some theroputic effect on colitis in mice ,and the mechanism maybe due to its regulation effcet on adipokines .
出处
《胃肠病学和肝病学杂志》
CAS
2015年第4期418-420,共3页
Chinese Journal of Gastroenterology and Hepatology