P53基因密码子72多态性与大肠癌易感性的Meta分析

Correlation between P53 gene codon 72 polymorphism and risk of colorectal cancer:a Meta-analysis

目的探讨P53基因密码子72多态性与大肠癌风险的相关性。方法全面检索Pub Med、Medline、EMbase、CBM、CNKI、万方和维普等数据库。检索时间从建库至2014年2月,收集P53基因密码子72多态性与大肠癌易感性的病例对照研究。采用Rev Man 5.2软件计算合并效用量OR及其95%CI。结果共纳入25个研究,其中有6 753例患者,8 562例对照者。Meta分析发现,在各遗传模型中,隐性模型PP vs AP+AA中P53基因密码子72多态性与大肠癌发生风险有明显相关性,其余基因模型中P53基因密码子72多态性与大肠癌发生风险无明显相关性。结论在PP vs AP+AA遗传模型中,P53基因密码子72多态性与大肠癌风险性显著相关。

Objective To investigate the correlation between P 53 gene codon 72 polymorphism and risk of colorectal cancer （CRC）.Methods A comprehensive research was conducted in these databases , such as PubMed, Medline, EMbase, CBM, CNKI, VIP, etc.The retrieval time from building of a database to Feb .2014.All eligible case-control study about the correlation between P 53 gene codon 72 polymorphism and colorectal cancer susceptibility were collected . Pooled odds ratios （OR） with 95%confidence intervals （95%CI） were calculated by the RevMan 5.2 software.Re-sults A total of 25 studies included 6 753 cases of patients and 8 562 cases of controls .Meta-analysis showed that there was significant correlation between the P 53 gene codon 72 polymorphism and colorectal cancer susceptibility in PP vs AP＋AA recessive model .There was no significant correlation between P 53 gene codon 72 polymorphism and colorectal cancer susceptibility in the remaining gene models .Conclusion There is significant correlation between the P 53 gene codon 72 polymorphism and colorectal cancer susceptibility in PP vs AP ＋AA model.