2型糖尿病中幽门螺杆菌感染与早期肾损害的关系

Study on the relationship between infection of Helicobacter pylori and early renal damage in type 2 diabetes

目的 探讨2型糖尿病中幽门螺杆菌（HP）感染与早期肾功能损害的关系.方法 收集在本院健康管理中心体检的2型糖尿病患者资料223例,进行整理分析,根据HP感染的情况分为HP阳性组和HP阴性组.比较两组患者一般情况及检测两组血脂、脂蛋白、24h尿蛋白、纤维蛋白原、C反应蛋白、血沉、尿素氮和血肌酐等情况.结果 两组中一般资料差异无统计学意义,血糖、糖化血红蛋白及血脂等差异无统计学意义（P＞0.05）.HP阳性组中α脂蛋白、24h尿蛋白定量、纤维蛋白原、C反应蛋白及血沉均高于HP阴性组,差异有统计学意义（P＜0.05）.结论 HP感染在2型糖尿病患者肾脏损害发生中起着一定的作用.

Objective To investigate the relationship between infection of Helicobacter pylori （HP） and early renal damage in type 2 diabetes.Methods Materials of 223 customer cases who received physical examination in our department were collected and analyzed.They were divided into two groups：HP positive group and HP negative group according to the HP infection.The basic information,blood lipid,lipoprotein,albuminuria of 24 hours,fibrinogen,C-reactive protein,erythrocyte sedimentation rate,and blood urea nitrogen and creatinine were compared between two groups,respectively.Results There was no significant difference in basic information,blood glucose,glycosylated hemoglobin and blood lipid （P 〉 0.05）.The results of lipoprotein,albuminuria of 24 hours,fibrinogen,C-reactive protein,and erythrocyte sedimentation rate in HP positive group were higher than those in HP negative group （P 〈 0.05）.Conclusions The infection of Helicobacter pylori played a part in the early renal damage of type 2 diabetes.