老年人脑萎缩与颈内动脉虹吸部钙化积分的相关性研究

Study of correlation between the elder brain atrophy and calcification score at siphon segment of internal carotid artery

目的：探讨老年人脑萎缩与颈内动脉虹吸部钙化积分的相关性。方法对327例老年人进行颅脑CT检查，观察脑萎缩的发生情况，测定并计算颈内动脉虹吸部钙化积分。根据钙化积分将其分为钙化0分组、钙化1～199分组、钙化200～399分组、钙化400～599分组及钙化≥600分组。比较各组脑萎缩情况，并分析钙化积分与脑萎缩的关系。结果根据颈内动脉虹吸部钙化积分分组，钙化0分组63例，钙化1～199分组133例，钙化200～399分组72例，钙化400～599分组28例，钙化≥600分组31例。钙化0分组中有脑萎缩13例（20．63％），钙化1～199分组中有脑萎缩64例（48．12％），钙化200～399分组中有脑萎缩51例（70．83％），钙化400～599分组中有脑萎缩23例（82．14％），钙化≥600分组中有脑萎缩28例（90．32％）；各组间脑萎缩患病率的比较差异有统计学意义（均P＜0．05）。钙化0分组及钙化1～199分组脑萎缩以轻－中度为主；钙化200～399分组脑萎缩以重度为主；钙化400～599分组及钙化≥600分组脑萎缩以中－重度为主（均P＜0．05）。 Spearman等级相关分析显示，脑萎缩程度与颈内动脉虹吸部钙化积分分值呈正相关（ r＝0．717， P＜0．05）。结论老年人脑萎缩与颈内动脉虹吸部钙化积分显著相关，钙化积分越大，脑萎缩的患病率越高，程度越重。颈内动脉虹吸部钙化积分可以作为预测老年人罹患脑萎缩的一项重要指标。

Objective To explore the correlation between the elder brain atrophy and calcification score at siphon segment of internal carotid artery.Methods The brain CT examination was detected in 327 elders.The brain atrophy occurrence were observed, and the calcification score at siphon segment of internal carotid artery were determined and calculated.Accroding to the calcification score, all the cases were divided into calcification 0 score group, calcification 1-199 score group, calcification 200-399 score group, calcification 400-599 score group and calcification ≥600 score group.The situation of brain atrophy were compared among these groups.And the correlation between the brain atrophy and calcification score were analyzed.Results Accroding to the calcification score, there were 63 cases in calcification 0 score group, 133 cases in calcification 1-199 score group, 72 cases in calcification 200-399 score group, 28 cases in calcification 400-599 score group and 31 cases in calcification ≥600 score group.There were 13 cases （ 20.63%） of brain atrophy in calcification 0 score group, 64 cases （48.12%） in calcification 1 -199 score group, 51 cases （70.83%） in calcification 200 -399 score group, 23 cases （82.14%） in calcification 400-599 score group and 28 cases （90.32%） in calcification≥600 score group;the differences of the brain atrophy rate among these groups were statistical significant （ all P〈0.05 ） .The brain atrophy was mainly mild-moderate in calcification 0 score group and calcification 1 -199 score group;which was mainly severe in calcification 200 -399 score group;and mainly moderate-severe in calcification 400 -599 score group and calcification≥600 score group （all P〈0.05）.Spearman rank correlation analysis showed that the degree of brain atrophy were positive correlated with calcification score at siphon segment of internal carotid artery （ r=0.717, P〈0.05） .Conclusions The elder brain atrophy is significantly correlated with calcification score at siphon segment of internal carotid artery.The calcification score higher, the brain atrophy rate higher and the degree more severe.Calcification score can be used as an important indicator of the elder brain atrophy.