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DNA传感器及其免疫信号传导通路的研究新进展

Process in DNA sensor and its immune signaling pathways
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摘要 DNA于哺乳动物细胞质中的存在是一个危险信号,提示机体内微生物感染的存在。近五年来的研究显示,细胞质DNA的传导机制是免疫系统产生免疫应答的分子基础。迄今为止已报道多种DNA传感器,其中STING是一个关键的衔接蛋白,参与大部分DNA信号传导途径。最近,c GAS-c GAMP第二信使通路、IFI16及其他传感器的发现为解析胞质DNA识别的分子机制提供了新见解。这些重要的发现有助于了解宿主防御系统,提高疫苗免疫原性,为感染性疾病的预防与治疗提供新思路。 The presence of DNA in the cytoplasm of mammalian cells is a danger signal, alerting the host to the presence of microbial infection. Over the past five years, research has shown that the cytoplasm DNA-sensing mechanism is the molecular basis of the immune system to produce the immune response. To date many cytosolic receptors of DNA have been proposed, but STING is a key adaptor protein for most DNA-sensing pathways. The recent discovery of the cGAS-cGAMP second messenger pathway as well as IFI16 and additional sensors collectively provide critical insights into the molecular basis behind the sensing of cytoplasmic DNA. These important discoveries help to understand the host defense system, improve the vaccine immunogenicity, unveil new avenues for the prevention and treatment of infectious diseases.
作者 尉冰 吕昌龙
机构地区 中国医科大学免疫学研究所
出处 《微生物学免疫学进展》 2015年第1期54-58,共5页 Progress In Microbiology and Immunology
基金 国家自然科学基金项目(31270972)
关键词 STING 环鸟甘酸-腺苷酸合成酶(cGAS) Toll样受体-9(TLR-9) DNA疫苗 Stimulator of interferon genes （STING） Cyclic GMP-AMP synthase Toll-like rceptor-9 DNA vaccine
分类号 R392.1 [医药卫生—免疫学]
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参考文献35

  • 1Ishikawa H,Ma Z,Barber GN.STING regulates intracellular DNA-mediated,type I interferon-dependent innate immunity[J].Nature,2009,461(7265):788-792.
  • 2Sun W,Li Y,Chen L,et al.ERIS,an endoplasmic reticulum IFN stimulator,activates innate immune signaling through dimerization[J].Proc Natl Acad Sci USA,2009,106(21):8653-8658.
  • 3Zhong B,Yang Y,Li S,et al.The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation[J].Immunity,2008,29(4):538-550.
  • 4Jin L,Waterman PM,Jonscher KR,et al.MPYS,a novel membrane tetraspanner,is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals[J].Mol Cell Biol,2008,28(16):5014-5026.
  • 5Ishikawa H,Barber GN.STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling[J].Nature,2008,455(7213):674-678.
  • 6Burdette DL,Vance RE.STING and the innate immune response to nucleic acids in the cytosol[J].Nat Immunol,2013,14(1):19-26.
  • 7Manzanillo PS,Shiloh MU,Portnoy DA,et al.Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages[J].Cell Host Microbe,2012,11(5):469-480.
  • 8Woodward JJ,Iavarone AT,Portnoy DA.c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response[J].Science,2010,328(5986):1703-1705.
  • 9Tsuchida T,Zou J,Saitoh T,et al.The ubiquitin ligase TRIM56regulates innate immune responses to intracellular double-stranded DNA[J].Immunity,2010,33(5):765-76.
  • 10Zhong B,Zhang L,Lei C,et al.The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA[J].Immunity,2009,30(3):397-407.

二级参考文献14

  • 1Wolff JA, Malone RW, Williams P, et al. Direct gene transfer into mouse muscle in vivo[ J ]. Science, 1990,247 (4949 Pt 1 ) : 1465-1468.
  • 2Hemmi H, Takeuchi O, Kawai T, et al. A Toll-like receptor recognizes bacterial DNA [ J ]. Nature, 2000,408 (6813 ) : 740-745.
  • 3Lladser A, Mougiakakos D, Tufvesson H, et al. DAI (DLM- 1/ZBPI ) as a genetic for DNA vaccines that promotes effective antitumor CTL immunity[J]. Mol Ther, 2011,19 ( 3 ) : 594- 601.
  • 4Lippmann J, Rothenburg S, Deigendesch N, et al. IFN- re- sponses induced by intracel]u]ar bacteria or cytoso]ic DNA in different human cells do not require ZBP] (DLM-I/DAI) [J]. Cell Microbiol,2008 ,I0(12) :2579-2788.
  • 5BurckstUmmer T, Baumann C, BlUml S, et al. An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome [ J]. Nat Immunol, 2009,10 (3) :266-272.
  • 6Rathinam VA, Jiang Z, Waggoner SN,et al. The AIM2 inflam- masome is essential for host defense against cytosolic bacteria and DNA viruses[ J]. Nat Immunol,2010,11 (5) :395-402.
  • 7Ahlasscr A, Baucrnfcind F, Hartmann G. RIG-I-dependent sensing of poly( dA: dT) through the induction of an RNA poly- merase Ill-transcribed RNA intermediate [ J ]. Nat Immuno], 2009, 10 ( 1 0 ) : 1065-I072.
  • 8Ishii KJ, Kawagoe T, Koyama S, et al. TANK-blnding kinase-1 delineates innate and adaptive immune responses to DNA vac- cines [ J]. Nature, 2008,451 ( 7179 ) :725-729.
  • 9Coban C, Kobiyama K, Aoshi T , et al. Novel strategies to imo prove DN A vaccine immunogenicity [ J ]. Curr Gene Tlner, 2011 , 11 (6) :479-484.
  • 10Stevceva L. Toll-like receptor agonists as adjuvants for HIV vae- cines[J]. Curr Med Chem ,2011,18 ( 33 ) :5079-5082.

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微生物学免疫学进展
2015年 第1期

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