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Th17细胞在衣原体感染中的作用研究 被引量：2

Role of Th17 cells in chlamydial infection
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摘要 衣原体是一类专性细胞内寄生的原核细胞型微生物,是感染人和动物常见的病原体之一,能够引起人和动物的多种疾病。近年来的研究表明,Th17细胞可能通过多种途径,在衣原体的免疫机制中发挥重要作用。虽然Th17细胞的生物学特征及其在炎症和自身免疫疾病的功能研究很多,但Th17细胞在衣原体感染中的作用机制尚不完全清楚,本文仅就对Th17细胞在衣原体感染中的诱导、发生、发育、分化等机制和免疫调节效应的研究进展予以简要综述。 Chlamydia is a type of obligate intracellular prokaryotic microorganisms.It is one of the most common patho-gens,which cause a variety of diseases in humans and animals.Recent research indicates that Th17 cells play an important role in the immunologic mechanism of chlamydia through multiple ways.Although a lot of functional studies have been con-ducted on the biological characteristics,inflammation and autoimmune disease of Th17,mechanism of action of Th17 cells in chlamydia is not clear at present.This paper reviews some progresses in the mechanisms and immune modulation effects of Th17 cells such as induction,infection,development,differentiation in chlamydia.
作者 陈彦波 吴移谋
机构地区 南华大学病原生物学研究所
出处 《微生物学免疫学进展》 2015年第2期45-48,共4页 Progress In Microbiology and Immunology
基金 国家自然科学基金(31270218)
关键词 TH17 衣原体 感染 作用 Th17 Chlamydia Infection Role
分类号 R518 [医药卫生—内科学]
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参考文献22

  • 1Moore-Connors JM, Fraser R, Halperin SA, et al. CD4(+)CD25 (+) Foxp3 (+) regulatory T cells promote Thl7 responses and gen- ital tract inflammation upon intraeellular Chlamydia muridarum in- fection[J]. J Immunol, 2013,191(6) : 3430-3439.
  • 2Park H, Li Z, Yang XO,et al. A distinct lineage of CIM T cells regulates tissue inflammation by producing interleukin 17[ JJ. Nat Immunol, 2005, 6(11) : 1133-1141.
  • 3Moseley TA, Haudenschild DR, Rose L, et al. Interleukin-17 family and IL-17 receptors [J]. Cytokine Growth Factor Rev, 2003,14(2) : 155-174.
  • 4Matsuzaki G, Umemura M. lnterleukin-17 as an effector molecule of innate and acquired immunity against infections [ J]. Microbiel Immunol, 2007,51 (12) : 1139-1147.
  • 5Harris TJ, Grosso JF, Yen HR,et al. Cutting edge: An in vivo re- quirement for STAT3 signaling in TH17 development and TH17- dependent autoimmunity [ J ]. J Immunol, 2007,179 ( 7 ) : 4313- 4317.
  • 6Stumhofer JS, Laurence A, Wilson EH,et al. Interleukin 27 nega- tively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous sys- tem [ J ]. Nat Immuno1,2006,7 (9) : 937-945.
  • 7张效云,徐志伟,高丽芬,陈丽丽,钟光明.IL-17在沙眼衣原体呼吸道感染中的早期表达及其与机体防御关系[J].河北北方学院学报（医学版）,2009,26(4):7-10. 被引量：1
  • 8Nakamura R, Shibata K, Yamada H, et al. Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by gammadelta T cells[J]. J Im- mnnol, 2008, 181(3): 2071-2075.
  • 9Michel ML, Keller AC, Paget C ,et al. Identification of an IL-17- producing NK1.1 (neg) iNKT cell population involved in airway neutrophilia[ J 1. J Exp Med, 2007, 204 ( 5 ) : 995-1001.
  • 10Potzl J, Botteron C, Tausch E,et al. Tracing functional antigen- specific CCR6 Thl7 cells after vaccination [ J ]. PLoS One, 2008, 3(8) : e2951.

二级参考文献35

  • 1Morrison RP,Caldwell HD. Immunity to murine chlamydial genital infeetion[J]. Infecl Immun,2002,70(6) :2741 -2751.
  • 2Morrison SG, Morrison RP. A predominant role for antibody in acquired immunity to chlamydial genital tract reinfection[J]. J Immunol,2005,175(11) :7536 -7542.
  • 3Kimura A,Naka T,Kishimoto T. IL-6 -dependent and- independent pathways in the development of interleukin 17 producing T helper cells[J]. Proc Natl Acad Sci USA, 2007, 104(29):12099 -12104.
  • 4Rouvier E, Luciani MF, Mattei MG, ct al. CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instabilily sequences, and homologous to a herpesvirus saimiri gene[J]. J Immunol,1993,150(12) :5445 -5456.
  • 5Chabaud M, Fossiez F, Taupin JL, et al. Enhancing effects of IL-17 on IL-1-induced IL-6 and leukemia inhibitory factor production by rheumatoid arthr tis synoviocytes and its regulation by Th2 cytokines[J]. J Immunol, 1998,161 ( 1 ) : 409- 414.
  • 6Jovanovic DV, Battista JA, Martel P J, et al. IL-17 stimulates the production and expression of proinflammatory cytokines,IL-1h and TNF-a by human macrophages[J]. J Immunol, 1998,160(7) : 3513-3521.
  • 7Andoh A,Fujino S,Bamba S,el al. IL-17 selectively down- regulates TNF-a-induced RANTES gene expression in human colonic subepithelial myofibrobIasts[J]. J Immunol, 2002,169(4) :1683- 1687.
  • 8Maertzdorf J, Osterhaus AD, Verjans GM. IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts[J]. J Immunol, 2002,169 (10) : 5897-5903.
  • 9Langrish CL,Chen Y,Blumenschein WM,et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation[J].J Exp Med,2005,201(2) :233-240.
  • 10Yen D,Cheung J,Scheerens H,et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6[J].J Clin Invest,2006,116(5):1310-1316.

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微生物学免疫学进展
2015年 第2期

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