摘要
孕激素是一种免疫调节分子,它主要通过与孕激素受体结合发挥免疫调节作用。大量研究证实,孕激素受体在多种淋巴细胞表达,孕激素在免疫调节中可诱导Th2细胞反应,抑制Th1细胞反应,抑制巨噬-单核细胞、自然杀伤细胞的杀伤活力。血清孕激素水平降低,孕激素受体表达调节障碍将影响自身免疫功能的调节,导致自身免疫性疾病的发生和发展。
Progesterone is an immunomodulatory molecule,its major immunomodulatory activities are mediated and then produced by progesterone in combination with related receptors.Numerous studies have been confirmed that progesterone receptor expressed in multiple lymphocytes,the immunomodulatory activities of progesterone are able to induce Th2 cell re-sponse,and inhibit Th1 cell response,as well as suppress killing activities from NK cell and macrophage /monocyte.Lower level of progesterone in sera and impaired progesterone receptor expression have been identified in autoimmune diseases, which may result in an attenuation in the immunomodulatory effect of progesterone,and contribute to the initiation and pro-gression of autoimmune diseases.
出处
《微生物学免疫学进展》
2015年第2期49-52,共4页
Progress In Microbiology and Immunology
基金
国家自然科学基金(81260593)
广西壮族自治区自然科学基金(2012GXNSFAA053101)
广西壮族自治区教育厅科研项目(201203YB105)
关键词
孕激素
孕激素受体
淋巴细胞
免疫调节
自身免疫性疾病
Progesterone
Progesterone receptor
Lymphocytes
Immune regulation
Autoimmune diseases
