正常孕妇血浆D-二聚体的检测的临床分析

Clinical analysis of normal maternal plasma D-dimer testing

目的检测正常孕妇不同孕期血浆D-二聚体（D-D）的水平变化。方法选取妊娠早期（〈12周）、妊娠中期（12~28周）、妊娠晚期（28周~分娩前）及产褥期（分娩至产后5 d）孕产妇及健康非孕妇女各100例,检测其血浆D-二聚体浓度,结果进行统计学分析。结果妊娠组血浆D-D水平明显升高,且与非妊娠组比较具有显著性差异（P〈0.05）;与早期妊娠组比较,中期妊娠组、晚期妊娠组及产褥期D-D水平均明显升高（P〈0.05）;而晚期妊娠组和产褥期D-D水平较中期妊娠组明显升高（P〈0.05）;产褥期D-D水平较晚期妊娠组明显升高（P〈0.05）。结论妊娠期血浆D-D水平会明显升高,且随着孕周增加,D-D水平会逐渐升高,对孕妇妊娠过程进行D-D动态监测,有助于预防分娩过程中及产后可能出现的异常出血,具有重要的临床指导意义。

Objective To detect pregnancy plasma D-dimer （ DD） of normal levels in pregnant women. Methods Early pregnancy （〈12 weeks）, the second trimester （12 weeks-28 weeks）, the third trimester （28 weeks-before birth） and postpartum （ birth to postpartum 5d） maternal and healthy non-pregnant women each 100 cases detected D-dimer plasma concentration, the results were statistically analyzed.Results Pregnancy plasma DD levels were significantly increased, and with the non-pregnant group significant difference （ P 〈0.05）;compared with early pregnancy group, mid-pregnancy group, the third trimester of pregnancy and the postpartum DD group were significantly higher （P〈0.05）;and third trimester of pregnancy and the postpartum group DD levels were significantly increased （ P 〈0.05） compared with the mid-pregnancy group; DD levels postpartum late stage of pregnancy were significantly higher （P〈0.05）.Conclusions DD plasma levels during pregnancy significantly increased with increasing gestational age and, DD levels will gradually rise, for pregnant women during pregnancy were DD dynamic monitoring, help prevent the delivery process may appear abnormal postpartum bleeding and, has important clinical significance.