左卡尼汀注射液辅助治疗老年冠心病心力衰竭78例疗效观察

Observation on the efficacy of L-carnitine injection in adjuvanttreating heart failure caused by coronary heart disease in 78 patients

目的观察分析左卡尼汀注射液辅助治疗老年冠心病心力衰竭的临床治疗效果。方法将选取2012年3月至2014年6月我院收入治疗的78例老年冠心病心力衰竭患者,随机分为对照组和观察组,对照组38例患者采用常规治疗(主要包括利尿剂、硝酸酯类药物治疗),观察组40例患者在常规治疗基础上加用左卡尼汀注射液辅助治疗,比较两组患者治疗半月后的心功能指标,治疗有效率情况差异。结果两组患者治疗半月后的左室收缩末期容积(LVESD)、左室舒张末期容积(LVEDD)、心输出量(CO)及左室射血分数(LVEF)均有所改善,但观察组患者治疗后的各项心功能指标较同期对照组患者优势显著,P<0.05;观察组总治疗有效率为97.5%较对照组81.6%的总治疗有效具有明显优势,P<0.05。结论左卡尼汀注射液辅助治疗老年冠心病心力衰竭患者可以有效改善患者的心功能,提高患者的临床治疗有效,利于患者的康复,值得应用。

Objective This paper was to observe and analyze the efficacy of L-carnitine injection adjuvant therapy in treating heart failure caused by coronary heart diseasein 78elderly patients.Methods 78 patients in our hospital from March 2012 to June 2014 were selected, randomly divided into control group and observation group, 38 patients in control group were treated with conventional treatment （ including diuretics, nitrates treatment） and 40 patients in observed group adopted L-carnitine injection adjuvant therapybased on the regular treatment, comparing differences in the efficiency of the situation, cardiac function of the two groups after a half months＆#39;treatment.Results After a half months＆#39;treatment, the indexes including Left ventricular end-systolic volume （ LVESD ） , left ventricular end-diastolic volume （ LVEDD ） , cardiac output （ CO ） and left ventricular ejection fraction （ LVEF） of two groups were improved, however, the cardiac function of observed group after treatment compared with the same period in the control group having a significant advantage （ P〈0.05）.The total effective rate of observed group was （97.5%） significantly higher than that of control group （81.6%）（P〈0.05）.Conclusions The application of L-carnitine injection adjuvant therapy in elderly patients with coronary heart disease can effectively improve cardiac function and improving clinical effective of patients, conducive to the rehabilitation of patients, it is worth of application.