参麦注射液联合化疗对结直肠癌Lovo细胞的增殖抑制作用

Shen Mai injection combined with chemotherapy in colorectal cancer Lovo cell inhibition

目的:探讨参麦注射液在肿瘤抗血管生成作用的时间窗问题,即最佳用药时间。方法:建立荷瘤小鼠模型,观察参麦注射液联合草酸铂/氟尿嘧啶抑制肿瘤增殖作用并观察荷瘤小鼠生存期的影响。结果:参麦联合化疗对人肠癌LOVO细胞及HUVEC的增值抑制作用最明显,效果高于相同剂量化学药物或单药参麦注射液。动物实验结果表明,先给予参麦注射液后给予奥沙利铂对肠癌Lovo荷瘤裸鼠皮下移植瘤的抑制作用最大,瘤体体积及重量最小,对肿瘤细胞的杀伤作用最为明显,癌细胞体积减少明显。结论:化疗前给药可能是参麦注射液的抗血管生成最佳治疗时间,确切机制仍需进一步探讨研究。

Objective：To investigate the SMI was anti‐angiogenic effect in tumor time window problem that optimal treatment time .Methods：The tumor‐bearing mice were observed Shenmai injection combined with oxaliplatin /fluorouracil inhibit tumor proliferation and survival of tumor‐bearing mice outlook affect period .Results：shenmai combi‐nation chemotherapy cytotoxicity in human colon cancer cells and HUVEC Lovo most active ,significantly higher than the SMI was measured at the same chemotherapy drugs or simply using .Animal experiments show that SMI was first given after the administration of oxaliplatin Lovo cancer tumor‐bearing nude mice maximum inhibition ,tumor volume and mini‐mum weight ,tumor cell killing effect is most obvious ,cancer cell volume decrease significantly .Conclusion：The admin‐istration of chemotherapy may be shenmai injection of anti‐angiogenic best treatment time ,the exact mechanism needs further discussion and study .