摘要
目的:研究多发性骨髓瘤﹙MM﹚患者血清中Cys-C、VEGF及IL-6含量的变化,并探讨其临床意义。方法:全自动生化分析仪进行Cys-C检测。双抗体夹心酶联免疫吸附测定法﹙ELISA﹚检测90例多发性骨髓瘤患者及50例健康对照组血清中Cys-C、VEGF及IL-6含量,分析其与MM临床分期,肿瘤负荷的关系。结果:研究组患者血清中的Cys-c、VEGF和IL-6含量较正常对照组均明显升高,差异有显著性﹙P〈0.01﹚。随着临床分期增加,患者血清中的Cys-c、VEGF和IL-6含量递增趋势,各期间比较均有显著性差异﹙P〈0.01﹚。结论:MM患者血清中Cys-C、VEGF和IL-6的含量,可反映患者的肿瘤负荷,对MM病情的判断具有重要意义。
Objective: To investigate the clinical significance of the changes of cystatin-C、vascular endothelial growth factor ﹙VEGF﹚ and interleukin-6 ﹙IL-6﹚ level in multiple myeloma ﹙MM﹚. Methods: The cystatin-C level was detected by automatic biochemical analyzer and the serum levels of VEGF and IL-6 were detected by enzyme-linked immunosorbent assays in 90 patients with MM and 50 healthy controls. The relationship between the increased serum levels of these third cytokines and MM clinical stage. Results: The levels of serum Cys-C VEGF and IL-6 in multiple myeloma group were significantly higher than that in control group,which was statisticaly significant﹙P〈0.01﹚; The levels of serum Cys-C VEGF and IL-6 increased progressively according to clinic stages and it had significant difference among stages respectively ﹙P〈 0.01﹚. Conclusion: The levels of serum Cys-C VEGF and IL-6 has important significance to determine the condition of MM.
出处
《中外女性健康研究》
2015年第6期202-203,共2页
Women's Health Research