甲硝唑与阿米卡星清洗液对预防阑尾炎术后切口感染的研究

Study on effect of metronidazole and amikacin cleaning fluid on prevention of postoperative incision infections in patients with appendicitis

目的探讨甲硝唑与阿米卡星清洗液对预防阑尾炎术后切口感染的作用,为预防及控制阑尾炎术后切口感染提供理论依据。方法选取2014年3月1-30日医院收治的300例阑尾炎患者,随机分为试验组和对照组,各150例,采用相同手术方法切除阑尾缝合腹膜后,试验组使用甲硝唑与阿米卡星清洗液对切口进行清洗,对照组使用生理盐水对切口进行清洗,对比两组患者术后切口的感染情况。结果试验组甲级愈合139例、乙级愈合9例,感染2例,感染率为1.33%;对照组甲级愈合110例、乙级愈合24例,感染16例,感染率10.67%。结论甲硝唑与阿米卡星清洗液对预防阑尾炎术后切口感染效果明显,可有效降低阑尾炎术后切口感染率,值得在临床推广应用。

OBJECTIVE To explore the effect of metronidazole and amikacin cleaning fluid on prevention of postop‐erative incision infections in patients with appendicitis so as to provide theoretical basis for prevention and control of the postoperative incision infections .METHODS A total of 300 appendicitis patients who were treated in the hos‐pital from Mar 1 ,2014 to Mar 30 ,2014 were enrolled in the study and randomly divided into the experimental group and the control group ,with 150 cases in each .After the appendices were cut with the same surgical proce‐dures and the peritonea were closed ,the incisions of the experimental group were cleaned by using the metron‐idazole and amikacin cleaning fluid ,while the incisions of the control group were cleaned with the use of normal sa‐line .The incidence of postoperative incision infections was compared between the two groups of patients .RESULTS There were 139 cases of grade A incision healing in the experimental group and 110 cases in the control group;there were 9 cases of grade B incision healing in the experimental group and 24 cases in the control group;the in‐fections occurred in 2 cases in the experimental group with the infection rate of 1 .33% and occurred in 16 cases in the control group with the infection rate of 10 .67% .CONCLUSION Metronidazole and amikacin cleaning fluid can achieve significant effect on the prevention of the postoperative incision infections in the appendicitis patients and effectively reduce the incidence of the postoperative incision infections ,and it is worthy to be promoted in the hos‐pital .