饮酒与脂肪肝的关系研究

A study on the relationship between alcohol drinking and fatty liver

目的探讨不同酒精摄入量对脂肪肝发生率及其危险因素高血糖、高血脂等代谢紊乱的影响。方法选取2013年10—12月期间温州市中心医院体检中心394名体检人员进行问卷调查,并进行人体学和实验室指标测量作分析。结果经LSD-t检验,甘油三酯随着饮酒量增加而升高(P<0.05);高甘油三酯、高尿酸、高胆固醇在不同饮酒量组间的检出率差异有统计学意义(P均<0.05),经卡方线性趋势检验显示,高甘油三酯及高尿酸患病率随着酒精摄入量增加而升高(P均<0.05)。饮酒量在脂肪肝和非脂肪肝的分布差异无统计学意义(P>0.05)。二项分类变量Logistic回归分析显示,腰臀比超标、高血压、超重肥胖、高甘油三酯血症为脂肪肝的独立危险因素,但未见"日均饮酒量"是脂肪肝的独立危险因素。结论腰臀比超标、高血压、超重肥胖、高甘油三酯血症是脂肪肝的危险因素,饮酒虽可导致高甘油三酯、高尿酸患病率升高,但未发现饮酒对脂肪肝患病率的直接影响。

Objective To explore the relationship between alcohol drinking and fatty liver disease and its influencing factors.Methods From October to December,2013,a total of 394 people who underwent a physical examination in the medical examination center of Wenzhou central hospital were selected for this study.Anthroposomatology measurement and biochemical tests were conducted.Results There were significantly statistical differences of triglyceride,uric acid and cholesterol in different drinking groups （P〈0.05）.The prevalence of high triglyceride and uric acid were increased with alcohol consumption （P〈0.05）.There was no significant difference of alcohol consumption between fatty liver and non -fatty liver group （P =0.42）.Logistic regression showed that waist -hip ratio,hypertension,overweight,obesity and hypertriglyceridemia were risk factors of fatty liver,while daily alcohol consumption cannot be thought as risk factor yet. Conclusion Waist -hip ratio,hypertension,overweight -obesity and hypertriglyceridemia were the risk factors of fatty liver.Alcohol consumption could contribute to the prevalence of triglyceride and uric acid.