摘要
目的:探讨红花黄色素注射液对颅脑损伤大鼠的保护作用。方法:采用Feeney自由落体撞击装置制作大鼠颅脑损伤模型,观察给药后第3天、7天、14天各组大鼠脑含水量及血浆中白细胞介素6(IL-6)、神经元特异性烯醇化酶(NSE)、超氧化物歧化酶(SOD)、丙二醛(MDA)含量变化。结果:红花黄色素注射液60mg/kg、30mg/kg组能够显著降低模型大鼠给药后第3天、7天、14天脑含水量,并明显降低IL-6、神经元特异性烯醇化酶(NSE)及MDA含量,升高SOD含量。结论:红花黄色素注射液对于颅脑损伤具有较好的保护作用。
Objective： To investigate the protective effect of safflower yellower injection on the traumatic brain injury rats. Methods： Feeney method were used to establish traumatic brain injury model in rats. The brain water content,IL-6,NSE,SOD and MDA in plasma were detected at the 3days,7days,14 days after adminstration with Safflower yellower injection（ 60 mg / kg,30 mg / kg,15 mg / kg）. Results ： Safflower yellower injection（ 60 mg / kg,30 mg / kg） significantly decreased the brain water content,reduced IL-6,NSE,MDA,and increased SOD in plasma at the3 days,7 days,14 days after adminstration obviously（ P 〈0. 05,P 〈0. 01）. Conclusion： Safflower yellower injection has obvious Protective effect on traumatic brain injury.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2015年第1期90-92,共3页
Pharmacology and Clinics of Chinese Materia Medica
基金
吉林省教育厅科技重点项目(吉教科合字【2014】第74号)
