甘肃不同产地黄芩茎叶的抗炎作用研究

Anti-inflammatory effect on stems and leaves of Scutellaria baicalensis from different areas of Gansu Province

目的:研究甘肃不同产地黄芩茎叶水煎液的抗炎作用。方法:采用1%角叉菜胶建立大鼠足肿胀模型、2%角叉菜胶建立大鼠胸膜炎模型,观察甘肃不同产地黄芩茎叶水煎液的抗炎活性。检测模型大鼠的足肿胀度及肿胀足中前列腺素E2(PGE2)含量,检测胸膜炎大鼠血清中一氧化氮(NO)及肿瘤坏死因子α(TNF-α)含量,探讨其抗炎作用。结果:致炎3h和4h时,不同产地黄芩茎叶水煎液(6g/kg)均能显著降低大鼠足肿胀度,均能降低大鼠足组织PGE2含量,其中漳县和陇西产黄芩茎叶的作用较强;不同产地黄芩茎叶水煎液(6g/kg)均能显著降低胸膜炎大鼠血清NO和TNF-α含量;其中其中漳县和陇西产黄芩茎叶的作用较强。结论:甘肃不同产地黄芩茎叶均有显著的抗炎作用,其中甘肃陇西、漳县产黄芩茎叶抗炎作用较优。

Objective： To study the anti-inflammatory effects on stems and leaves of Scutellaria baicalensis from different areas of Gansu Province.Methods： Paw edema model and pleurisy model induced by carrageenan in rats were used for anti-inflammatory experiments. Paw swelling degrees and prostaglandin E2（ PGE2） content in footpad were determined,and the content of nitric oxide（ NO） and tumor necrosis factor alpha（ TNF-α） in serum of pleurisy rats were measured to explore the anti-inflammatory effect. Results： After given with stems and leaves of Scutellaria baicalensis decoction by intragastric administration（ 6g / kg）,the rat paw swellings were reduced at 3h or 4h（ P〈0. 05）,and the content of PGE2 in rat paw tissue was decreased（ P〈0. 05）,The NO and TNF-α content in serum were significantly reduced the pleurisy rats（ P〈0. 05）,the effects of production of Zhangxian and Longxi are stronger（ P〈0. 05）. Conclusion： There was a significant anti-inflammation activity on stems and leaves of Scutellaria baicalensis in different areas of Gansu Province,The anti-inflammatory effect of productions from Longxi and Zhangxian are better.