重庆地区膀胱癌人群IL-23R rs10889677位点单核苷酸多态性与膀胱癌易感性的相关性分析

Analysis in correlation between polymorphism of IL-23R gene rs10889677 and susceptibility of bladder cancer in Chongqing area

目的分析白介素23受体（IL-23R）基因rs10889677位点单核苷酸多态性（SNPs）与重庆地区膀胱癌人群易感性的相关性。方法选取来自重庆地区的膀胱癌组患者210例和健康对照组人群200例,采用聚合酶链式反应-限制性片段长度多态性（PCR-RFLP）技术检测IL-23R rsl10889677位点SNPs并分析其与膀胱癌的关系。结果 IL-23R基因rs10889677位点存在三种基因型（AA型、AC型和CC型）,在膀胱癌组和对照组中的基因型频率分布差异有统计学意义（χ^2=17.45,P〈0.01）;膀胱癌组携带等位基因A的频率（75.71%）明显增高对照组基因型（65.50%）,差异有统计学意义[χ^2=19.28,P〈0.01,OR=1.952,95%CI（1.451~2.620）]。结论 IL-23R rs10889677位点基因多态性与重庆地区膀胱癌易感性相关。

Objective To analyze the correlation between the polymorphism of IL-23 R gene rs10889677 SNPs and susceptibility of bladder cancer in Chongqing area. Methods A total of 210 bladder cancer patients（bladder cancer group） and 200 healthy people（control group） were selected. The rs10889677 SNPs was analyzed by restriction fragment length poly（PCR-RFLP）,and its relationship with bladder cancer was analyzed as well. Results There were three kinds of genotypes in IL-23 R gene rs10889677（AA,AC and CC）. In the three single nucleotide polymorphisms of IL-23 R,the distributions of genotype and allele frequencies of rs10889677 differed significantly between the bladder cancer group and the control group. The frequency of allele A of rs10889677 in the bladder cancer group was 75. 71%,which was significantly higher than 65. 50% in the control group,and there was significant difference [χ^2= 19. 28,P〈 0. 01,odds ratio = 1. 952,95% confidence interval（1. 451 ~ 2. 620） ]. Conclusion The rs10889677 of IL-23 R gene is associated with susceptibility of bladder cancer in Chongqing area.